@article{article_1818742, title={Exercise and the Microbiota-Gut-Brain-Muscle Axis in Irritable Bowel Syndrome}, journal={İstanbul Esenyurt Üniversitesi Sağlık Bilimleri Dergisi}, volume={3}, pages={1–5}, year={2025}, author={Çırak, Nilgün and Koçak, Cahidenur}, keywords={İrritabl Bağırsak Sendromu, Egzersiz, İskelet Kası, Beyin-Bağırsak Aksı, Gastrointestinal Mikrobiyota}, abstract={Irritable bowel syndrome (IBS) is a common functional gastrointestinal condition marked by abdominal discomfort and irregular bowel movements. It is frequently associated with psychological symptoms and disturbances in gut microbiota. In recent years, attention has turned to the interconnected nature of the gut, brain, and skeletal muscle, described as the microbiota-gut-brain-muscle (MGB) axis. This review examines how exercise may support the management of IBS by influencing microbial composition, strengthening the intestinal barrier, regulating inflammation, and affecting neural pathways. Moderate aerobic exercise appears to ease gastrointestinal symptoms and enhance mental well-being, partly through immune and hormonal interactions. Current research suggests that mechanisms like myokine release, improved autonomic regulation, and vagal nerve activity may significantly influence IBS-related outcomes. Both controlled trials and real-world patient observations highlight the therapeutic value of tailored exercise interventions. Still, questions remain about how long-term exercise impacts the MGB axis, which warrants deeper exploration through future studies}, number={1}, publisher={İstanbul Esenyurt Üniversitesi}