@article{article_1818845, title={The Hidden Face of Obesity: The Role of Inflammation}, journal={İstanbul Esenyurt Üniversitesi Sağlık Bilimleri Dergisi}, volume={3}, pages={20–27}, year={2025}, author={Aray, Yaren and Dumlu Bilgin, Gözde}, keywords={Adipositokinler, beslenme, sitokinler, inflamasyon, obezite}, abstract={Aim: This study explores the interaction between elevated proinflammatory cytokines, part of the body’s inflammatory response, and obesity, also known as low-grade inflammation. The aim is to clarify whether the increased levels of adipocytokines contribute to the development of obesity or if obesity itself enhances the production of adipocytokines. Understanding the reciprocal relationship between these two factors could facilitate the development of new strategies for preventing and treating obesity-related complications. Results: In people with obesity, changes occur in various metabolic pathways as the body’s energy balance shifts, with inflammation being the primary driver of these alterations. Inflammation influences key adipokines such as adiponectin and leptin and interacts with other biological processes. The literature suggests that a diet rich in complex carbohydrates, high fiber, and low glycemic index foods is linked to reduced proinflammatory cytokines. The Mediterranean and anti-inflammatory diets are clinically recommended for managing inflammation. However, determining the root cause of inflammation requires a detailed exploration of several interconnected mechanisms. Conclusion: Determining the root cause of inflammation requires thorough examination. The ongoing debate is whether increased cytokine inflammatory responses trigger obesity, or whether obesity itself initiates inflammation by amplifying cytokine responses. Further research is needed to clarify the long-term implications of this complex relationship.}, number={1}, publisher={İstanbul Esenyurt Üniversitesi}