TY  - JOUR
T1  - The predictive value of laboratory parameters in diagnosing gastrointestinal malignancy in older adults
TT  - Yaşlı bireylerde gastrointestinal malignite tanısında laboratuvar parametrelerinin öngörü değeri
AU  - Yıldırım Borazan, Funda
AU  - Yılmaz, Meryem
AU  - Tuzcu, Barış
AU  - Gülbahar, Özlem
AU  - Göker, Berna
AU  - Varan, Hacer Doğan
PY  - 2026
DA  - March
Y2  - 2026
DO  - 10.17826/cumj.1848421
JF  - Cukurova Medical Journal
JO  - Cukurova Med J
PB  - Çukurova Üniversitesi
WT  - DergiPark
SN  - 2602-3032
SP  - 361
EP  - 368
VL  - 51
IS  - 1
LA  - en
AB  - Purpose: This retrospective study aimed to evaluate the predictive value of pre-endoscopic biochemical parameters for detecting malignant lesions in older adults undergoing upper and lower gastrointestinal (GI) endoscopies. Materials and Methods: We retrospectively analyzed 419 individuals aged 60 and above. Of these, 109 older adult patients who underwent both upper and lower GI endoscopies were included in the study. Patients with a prior history of GI cancer or those who could not complete the procedure due to intolerance were excluded. Patients were categorized based on the presence of benign or malignant lesions. Results: Malignant lesions were identified in 10.1% of patients (11/109). Statistically significant differences were observed between the benign and malignant groups in terms of hemoglobin (Hb), neutrophil count, mean corpuscular volume (MCV), neutrophil-lymphocyte ratio (NLR), iron (Fe), 25-hydroxyvitamin D [25(OH)D], C-reactive protein (CRP), total protein, albumin (Alb), blood urea nitrogen (BUN), CRP/albumin ratio (CAR), and aspartate aminotransferase (AST). The ROC curve analysis suggests that MCV, NLR, 25(OH)D, Fe, and CAR are valuable indicators for predicting malignant lesions in older adults, with optimal cut-off values of 79.5 fL, 3.28, 12 µg/L, 22 µg/dL, and 5.93, respectively. Conclusion: Laboratory parameters such as MCV, NLR, 25(OH)D, Fe, and CAR can support risk stratification when interpreted alongside clinical assessment and guideline-based recommendations.
KW  - Gastrointestinal Malignancy
KW  - Gastrointestinal endoscopy
KW  - Predictive
KW  - Older adult
KW  - Laboratory parameters
N2  - Amaç: Bu çalışmada, üst ve alt gastrointestinal (GI) endoskopi uygulanan yaşlı bireylerde malign lezyonların saptanmasında endoskopi öncesi biyokimyasal parametrelerin prediktif değerinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmada 60 yaş ve üzeri toplam 419 birey retrospektif olarak analiz edilmiştir. Bunlar arasından hem üst hem de alt GI endoskopi yapılan 109 yaşlı hasta çalışmaya dahil edilmiştir. Daha önce GI kanser öyküsü olan veya intolerans nedeniyle işlemi tamamlayamayan hastalar çalışma dışı bırakılmıştır. Hastalar benign veya malign lezyon varlığına göre gruplandırılmıştır. Bulgular: Hastaların %10,1’inde (11/109) malign lezyon saptanmıştır. Benign ve malign gruplar arasında hemoglobin (Hb), nötrofil sayısı, ortalama eritrosit hacmi (MCV), nötrofil-lenfosit oranı (NLR), demir (Fe), 25-hidroksivitamin D [25(OH)D], C-reaktif protein (CRP), total protein, albümin (Alb), kan üre nitrojeni (BUN), CRP/albümin oranı (CAR) ve aspartat aminotransferaz (AST) açısından istatistiksel olarak anlamlı farklılıklar bulunmuştur. ROC eğrisi analizi, MCV, NLR, 25(OH)D, Fe ve CAR’ın yaşlı bireylerde malign lezyonların öngörülmesinde anlamlı göstergeler olduğunu ortaya koymuştur. Bu parametreler için optimal kesim değerleri sırasıyla 79,5 fL, 3,28, 12 µg/L, 22 µg/dL ve 5,93 olarak belirlenmiştir. Sonuç: MCV, NLR, 25(OH)D, Fe ve CAR gibi laboratuvar parametreleri, klinik değerlendirme ve kılavuz temelli öneriler ile birlikte yorumlandığında risk sınıflandırmasını destekleyebilir.
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UR  - https://doi.org/10.17826/cumj.1848421
L1  - https://dergipark.org.tr/tr/download/article-file/5535901
ER  -