TY  - JOUR
T1  - Bagirsak Mikrobiyomu ve Probiyotiklerin Nörotransmitterler üzerine etkileri
TT  - The Gut Microbiome and the Effects of Probiotics on Neurotransmitters
AU  - Özalp, Tahir
AU  - Ural, Kerem
AU  - Erdoğan, Hasan
AU  - Paşa, Serdar
AU  - Erdoğan, Songül
AU  - Kizilkanat, Ayşe İdil
PY  - 2026
DA  - June
Y2  - 2026
JF  - Antakya Veteriner Bilimleri Dergisi
JO  - Antakya Veteriner Bilimleri Dergisi
PB  - Hatay Mustafa Kemal Üniversitesi
WT  - DergiPark
SN  - 2979-9805
SP  - 34
EP  - 47
VL  - 5
IS  - 1
LA  - tr
AB  - Bağırsak–beyin ekseni, bağırsak mikrobiyotası ile merkezi sinir sistemi arasında sinirsel, immünolojik ve metabolik yolaklar üzerinden çift yönlü iletişimi sağlayan karmaşık bir ağdır ve bu eksende vagus siniri, enterik sinir sistemi ve mikrobiyal metabolitler temel rol oynar. Son yıllarda artan kanıtlar, bağırsak mikrobiyotasının yalnızca gastrointestinal fizyolojiyi değil; duygu durum, biliş ve davranış gibi merkezi sinir sistemi işlevlerini de düzenlediğini göstermektedir. Mikrobiyota tarafından üretilen veya metabolize edilen nörotransmitterler (glutamat, GABA, serotonin, dopamin ve norepinefrin), bunların öncülleri (triptofan, tirozin) ve kısa zincirli yağ asitleri, afferent vagal yolaklar, enteroendokrin hücreler ve immün sinyalizasyon aracılığıyla beyin fonksiyonlarını etkileyebilmektedir. Bu derleme, bağırsak mikrobiyotası ile nörotransmisyon arasındaki ilişkiyi ayrıntılı biçimde ele alarak, mikrobiyal kaynaklı metabolitlerin nörotransmitter sentezi, salınımı ve reseptör düzeyindeki etkilerini tartışmaktadır. Ayrıca, bağırsak–beyin eksenindeki bozulmaların depresyon, anksiyete, otizm spektrum bozukluğu, Parkinson ve Alzheimer hastalığı gibi nöropsikiyatrik ve nörodejeneratif hastalıkların patofizyolojisiyle ilişkisi değerlendirilmektedir. Mevcut veriler, mikrobiyota hedefli yaklaşımların nörolojik ve psikiyatrik hastalıkların önlenmesi ve tedavisinde umut vadeden stratejiler sunabileceğini düşündürmektedir.
KW  - bağırsak-beyin ekseni
KW  - Mikrobiyota
KW  - Nörotransmiterler
KW  - Kısa zincirli yağ asitleri
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UR  - https://dergipark.org.tr/tr/pub/antakyavet/article/1862607
L1  - https://dergipark.org.tr/tr/download/article-file/5599295
ER  -