TY - JOUR T1 - Seasonal changes in oxidant and antioxidant biomarkers in liver and muscle of common carp (Cyprinus carpio) in Atatürk Dam Lake TT - Atatürk Baraj Gölü'nde yaşayan sazan balığı (Cyprinus carpio)'nın karaciğer ve kas dokusunda oksidan ve antioksidan biyobelirteçlerin mevsimsel değişimi AU - Şahin, Ayşe Gül AU - Öz, Özden AU - Erişir, Mine AU - Türkoğlu, Semra AU - Benzer, Fulya AU - Şahin, Hülya AU - Tepe, Rıdvan AU - Sünbül, Muhammet Raşit AU - Şeker, Tunay AU - Küçükyılmaz, Mehmet AU - Örnekci, Gürel AU - Yıldırım, Tacettin AU - Fırat, Özgür PY - 2026 DA - July Y2 - 2026 DO - 10.12714/egejfas.43.3.13 JF - Ege Journal of Fisheries and Aquatic Sciences JO - EgeJFAS PB - Ege Üniversitesi WT - DergiPark SN - 2148-3140 SP - 290 EP - 297 VL - 43 IS - 3 LA - en AB - Seasonal investigations were conducted on 640 Cyprinus carpio specimens obtained through commercial fishing at four different stations (Gerger, Sitilce, Hosirge, and Samsat) in the Atatürk Dam Lake. MDA (malondialdehyde) levels were measured in the liver and muscle tissues of male and female fish; the results revealed a significant increase in MDA levels at stations exposed to point-source discharge. This indicates that pollution-induced oxidative stress in fish varies significantly across seasonal and regional scales. Among the stations compared, the lowest MDA values were detected in fish tissues from the Gerger station, while the highest values were recorded at the Sitilce and Hosirge stations. Analysis of SOD, GSH-Px, and GSH values across all stations showed that these parameters fluctuated in correlation with MDA levels thereby maintaining the oxidant-antioxidant balance. This study investigated seasonal and spatial variations in oxidative stress biomarkers in common carp (Cyprinus carpio) collected from four stations in Atatürk Dam Lake. A total of 640 specimens were analyzed for malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and reduced glutathione (GSH) levels in liver and muscle tissues. Results showed that MDA levels were significantly higher in fish collected from Sitilce and Hosirge stations, indicating elevated lipid peroxidation associated with point-source pollution. In contrast, the lowest MDA levels were observed at the reference station, Gerger. Antioxidant enzyme activities (SOD, GSH-Px, and GSH) exhibited tissue-, season-, and site-dependent variations, suggesting adaptive responses to oxidative stress. Overall, the findings demonstrate that anthropogenic pressures in Atatürk Dam Lake significantly alter the oxidant–antioxidant balance in fish, highlighting the usefulness of these biomarkers for environmental monitoring. KW - Atatürk Dam Lake KW - Cyprinus carpio KW - oxidative stress KW - MDA KW - antioxidant enzymes KW - seasonal variation N2 - Atatürk Baraj Gölü'nde dört farklı istasyondan (Gerger, Sitilce, Hosirge ve Samsat) ticari balıkçılık yoluyla elde edilen 640 adet sazan (Cyprinus carpio) örneği üzerinde mevsimsel araştırmalar gerçekleştirilmiştir. Çalışmada, erkek ve dişi bireylerin karaciğer ve kas dokularında malondialdehit (MDA) düzeyleri ölçülmüş; nokta kaynaklı deşarja maruz kalan istasyonlarda MDA düzeylerinde anlamlı bir artış tespit edilmiştir. Bu bulgu, balıklarda kirliliğe bağlı oksidatif stresin mevsimsel ve bölgesel ölçekte önemli farklılıklar gösterdiğini ortaya koymaktadır. İstasyonlar karşılaştırıldığında, en düşük MDA değerleri referans istasyon olan Gerger'de, en yüksek değerler ise Sitilce ve Hosirge istasyonlarında belirlenmiştir. Tüm istasyonlarda süperoksit dismutaz (SOD), glutatyon peroksidaz (GSH-Px) ve glutatyon (GSH) düzeylerinin MDA ile ilişkili biçimde dalgalanarak oksidan-antioksidan dengesinin korunmasına katkıda bulunduğu belirlenmiştir. Antioksidan enzim aktiviteleri (SOD, GSH-Px ve GSH), dokuya, mevsime ve istasyona bağlı farklılıklar göstererek oksidatif strese karşı adaptif bir yanıt sergilemiştir. Sonuç olarak elde edilen bulgular, Atatürk Baraj Gölü'ndeki antropojenik baskıların balıklarda oksidan-antioksidan dengesini önemli ölçüde değiştirdiğini ve bu biyobelirteçlerin çevresel izleme çalışmalarında kullanışlı araçlar olduğunu göstermektedir CR - Abdallah, S.M., Muhammed, R.E., Mohamed, R.E., El Daous, H., Saleh, D.M., Ghorab, M.A., Chen, S., & El-Sayyad, G.S. (2024). Assessment of biochemical biomarkers and environmental stress indicators in some freshwater fish. 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