TY  - JOUR
T1  - Clinical Comparison of Different Detomidine Combinations in Rats
TT  - Ratlarda Farklı Detomidin Kombinasyonlarının Klinik Olarak Karşılaştırılması
AU  - Kılıç, Nuh
AU  - Öztürk, İlay
PY  - 2026
DA  - July
Y2  - 2026
DO  - 10.71255/maunsbd.1903708
JF  - Muş Alparslan Üniversitesi Sağlık Bilimleri Dergisi
PB  - Muş Alparslan Üniversitesi
WT  - DergiPark
SN  - 2792-0925
SP  - 36
EP  - 50
VL  - 6
IS  - 2
LA  - en
AB  - In this study, the clinical effects of detomidine, detomidine-ketamine, detomidine-ketamine-butorphanol, and detomidine-ketamine-diazepam combinations were compared in rats. A total of 32 rats were divided into four distinct groups. Each anesthesia group consisted of 8 rats with an equal sex distribution (4 males, 4 females). The experimental protocols were administered intraperitoneally as follows: Group D (n=8) received 0.1 mg/kg detomidine; Group DK (n=8) received 0.1 mg/kg detomidine and 75 mg/kg ketamine; Group DKB (n=8) received 0.1 mg/kg detomidine, 75 mg/kg ketamine, and 5 mg/kg butorphanol; and Group DKD (n=8) received 0.1 mg/kg detomidine, 75 mg/kg ketamine, and 5 mg/kg diazepam. Cardiopulmonary parameters (heart rate, respiratory rate, body temperature, peripheral oxygen saturation) and reflexes (pedal, palpebral, corneal, and interdigital) were evaluated in all four groups before anesthesia and at 5, 10, 15, 20, 25, 30, 45, 60, 90, and 120 minutes post-anesthesia. In terms of surgical and total anesthesia duration, the DK, DKB, and DKD groups were found to be significantly lower compared to Group D (P=0.000). Regarding reflex parameters, the disappearance times for pedal, palpebral, and corneal reflexes in the DKD group (P=0.035) and the interdigital reflex in the DKD group (P=0.023) were significantly shorter than those in Group D. Decreases in heart rate, peripheral oxygen saturation, and body temperature were observed across all four groups. In conclusion, it was determined that detomidine alone (Group D) did not provide adequate sedation or anesthesia in rats. The DKB combination is recommended for painful procedures, particularly orthopedic surgeries, due to its effective analgesia, while the DKD combination is suggested for surgical operations requiring prolonged anesthesia.
KW  - rat
KW  - anaesthesia
KW  - respiratory rate
KW  - hearth rate
KW  - detomidine
N2  - Bu çalışmada, ratlar üzerinde detomidin, detomidin-ketamin, detomidin-ketamin-butorfanol ve detomidin-ketamin-diazepam kombinasyonlarının klinik olarak etkileri karşılaştırıldı. Toplam 32 rat dört farklı gruba ayrıldı. Her anestezi grubunda cinsiyet dağılımı eşit olacak şekilde (4 erkek, 4 dişi) 8 adet rat yer aldı. 1. Grup D’ye (n=8) 0,1 mg/kg detomidin; 2. DK’ye (n=8) 0,1 mg/kg detomidin ve 75 mg/kg ketamin; 3.Grup DKB’ye (n=8) 0,1 mg/kg detomidin, 75 mg/kg ketamin ve 5 mg/kg butorfanol; 4. Grup DKD’ye (n=8) 0,1 mg/kg detomidin, 75 mg/kg ketamin ve 5 mg/kg diazepam intraperitoneal yolla uygulandı. Anestezi öncesi ve anestezi sonrası 5, 10, 15, 20, 25, 30, 45, 60, 90 ve 120 dakika kardiyopulmoner parametreler (kalp frekansı, solunum frekansı, vücut sıcaklığı, perifer oksijen satürasyonu) ve refleksler (pedal, palpebral, korneal, ayak parmak arası) her dört grupta incelendi. Cerrahi anestezi süresi ve toplam anestezi süresi bakımından D grubuna göre DK, DKB ve DKD grupları anlamlı düzeyde düşük (P=0,000) bulundu. Refleks parametreleri bakımından D grubuna göre pedal, palpebral ve korneal refleks kaybolma süreleri DKD grubu (P=0,035), ayak parmak arası refleksi kaybolma süresi DKD grubu (P=0,023) anlamlı düzeyde düşük bulundu. Kalp frekansı, perifer oksijen satürasyonu ve vücut sıcaklığı bakımından her dört grupta da düşüşler olduğu görüldü. Sonuç olarak, D grubu ratlarda tek başına kullanıldığında yeterli sedasyon ve anestezi oluşturmadığı tespit edildi. DKB grubu iyi bir analjezi sağladığından ağrılı özellikle ortopedik cerrahi operasyonlarda, DKD grubu ise uzun süreli anestezi sağladığından cerrahi operasyonlarda kullanımı önerilmektedir.
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UR  - https://doi.org/10.71255/maunsbd.1903708
L1  - https://dergipark.org.tr/tr/download/article-file/5786155
ER  -