@article{article_1913021, title={Cardiovascular Effects of Antiretroviral Therapy in Human Immunodeficiency Virus Patients: A Strain Echocardiography Study}, journal={Kafkas Journal of Medical Sciences}, volume={16}, pages={68–73}, year={2026}, url={https://izlik.org/JA65KC94XM}, author={Demir, Yusuf and Başkurt, Ahmet Anıl and Ceylan, Mehmet and Şenol, Güneş and Şenöz, Oktay}, keywords={Antiretroviral treatments, Human Immunodeficiency Virus, Strain echocardiography.}, abstract={Aim: The availability of antiretroviral treatments (ART) has transformed Human Immunodeficiency Virus (HIV) management, turning it from a fatal infection into a manageable chronic condition by effectively reducing viral replication and enhancing patient survival rates. Cardiovascular disease (CVD) is increasingly recognized as a leading cause of morbidity and death among people living with HIV, highlighting the need to monitor potential adverse effects of ART on the cardiovascular system. This study assessed the cardiovascular effects of ART in a cohort of HIV-infected patients by analyzing laboratory, echocardiographic strain, and demographic data before and after treatment. Material and Methods: A total of 56 patients who attended the infectious diseases clinic and were scheduled to receive ART treatment were included in the study. A comprehensive cardiovascular assessment, comprising anamnesis, electrocardiogram, and transthoracic strain echocardiography, was conducted before and three months after the initiation of ART therapy. Results: Examination of lipid parameter changes across treatment regimens revealed a statistically significant elevation in total cholesterol, low-density lipoprotein (LDL) cholesterol, and highdensity lipoprotein (HDL) cholesterol in the group treated with tenofovir alafenamide following treatment initiation. Regarding echocardiographic parameters evaluated post-treatment, there was no statistically significant change observed in left ventricular systolic function (LVEF) and diastolic function (septal E/e’ratio) (60.81±5.5 vs. 61.16±4.3, p=0.313, and 9.23±2.2 vs. 9.43±2.6, p=0.214, respectively). Notably, a significant improvement was observed in left ventricular global longitudinal strain (LV-GLS), with values changing from -18.74±2.9 to -19.75±2.4 (p <0.001). Conclusion: Our study demonstrates that ART can exert a beneficial influence on cardiovascular health by enhancing myocardial strain and diminishing inflammatory markers in patients infected with HIV.}, number={1}