TY  - JOUR
T1  - Evaluation of hemotoxic, nephrotoxic and hepatotoxic potential of phenol in Labeo rohita
TT  - Fenolün Labeo rohita balığında hemotoksik, nefrotoksik ve hepatotoksik potansiyelinin değerlendirilmesi
AU  - Ahmad, Shabbir
AU  - Akram, Iqra
AU  - Akmal, Hasnain
AU  - Maqsud, Shahroz
AU  - Shahzad, Khurram
AU  - Khan, Muhammad Saleem
PY  - 2026
DA  - July
Y2  - 2026
DO  - 10.12714/egejfas.43.3.08
JF  - Ege Journal of Fisheries and Aquatic Sciences
JO  - EgeJFAS
PB  - Ege Üniversitesi
WT  - DergiPark
SN  - 2148-3140
SP  - 251
EP  - 258
VL  - 43
IS  - 3
LA  - en
AB  - The current study aimed to investigate the effects of phenol on the haematology, biochemical parameters, and histopathology of Labeo rohita in the laboratory conditions. Three groups were maintained as control, low dose (0.30 mg/L) and high dose (0.40 mg /L). The results after 28 days exposure to phenols showed changes in hematological parameters as RBCs, WBC, PLT, HGB, MCH, MCHC, RDW and PCT significant decrease and HCT, MCV, RDW-SD, MPV, and PDW significant decrease as compared with control group. Similarly, phenol exposure showed significant alterations in biochemical parameters as decrease the level of cholesterol, triglycerides, HDL, blood glucose, total protein, TSH, albumin and globulin while increase the level of ALT, AST, T3, T4, urea and creatinine. Histological observations showed the damage caused by phenol in kidney tissues was sinusoidal spaces, elongated tubules, cluster nuclei formation, damages parenchyma and melano-macrophages. Histology of liver showed pyknotic nuclei formation, eosinophilic granules in cytoplasm, cytoplasmic vacuolation and necrosis. In gills, curved gills lamellae, oedema, lamellar aneurysm, lamellar disorganization, bone cell deformities and hyperplasia of epithelial cells were observed. Histology of muscles also showed pigmented cells around blood cells, necrosis, intermyofibrillar, oedema and atrophy in muscle tissues. The overall results showed that phenols are highly toxic to aquatic species.
KW  - Aquatic toxicity
KW  - phenols
KW  - hepatotoxicity
KW  - nephrotoxicity
KW  - fish
KW  - biochemistry
N2  - Bu çalışmanın amacı, laboratuvar koşullarında Labeo rohita balığının hematolojisi, biyokimyasal parametreleri ve histopatolojisi üzerindeki fenol etkilerini araştırmaktır. Kontrol, düşük doz (0,30 mg/L) ve yüksek doz (0,40 mg/L) olmak üzere üç grup oluşturulmuştur. 28 günlük fenol maruziyetinden sonra elde edilen sonuçlar, kontrol grubuyla karşılaştırıldığında, hematolojik parametrelerde RBC, WBC, PLT, HGB, MCH, MCHC, RDW ve PCT'de anlamlı azalma ve HCT, MCV, RDW-SD, MPV ve PDW'de anlamlı azalma olduğunu göstermiştir. Benzer şekilde, fenol maruziyeti, kolesterol, trigliserit, HDL, kan şekeri, toplam protein, TSH, albümin ve globulin seviyelerinde azalma, ALT, AST, T3, T4, üre ve kreatinin seviyelerinde ise artış gibi biyokimyasal parametrelerde önemli değişiklikler göstermiştir. Histolojik gözlemler, böbrek dokularında fenolün neden olduğu hasarın sinüzoidal boşluklar, uzamış tübüller, küme çekirdek oluşumu, parankima hasarı ve melano-makrofajlar olduğunu göstermiştir. Karaciğer histolojisi, piknotik çekirdek oluşumu, sitoplazmada eozinofilik granüller, sitoplazmik vakuolasyon ve nekroz göstermiştir.Solungaçlarda eğri solungaç lamelleri, ödem, lameller anevrizma, lameller düzensizlik, kemik hücresi deformiteleri ve epitel hücrelerinin hiperplazisi gözlenmiştir. Kasların histolojisi ayrıca kan hücreleri çevresinde pigmentli hücreler, nekroz, intermiyofibriller ödem ve kas dokularında atrofi göstermiştir. Genel sonuçlar, fenollerin sucul türler için oldukça toksik olduğunu ortaya koymuştur.
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UR  - https://doi.org/10.12714/egejfas.43.3.08
L1  - https://dergipark.org.tr/tr/download/article-file/5834007
ER  -