TY  - JOUR
T1  - Comparison of anti-edema effects of iloprost and diclofenac sodium on traumatic rat paw edema
AU  - Uslu, Mustafa
AU  - Kilincoglu, Volkan
AU  - Toker, Serdar
AU  - Kalender, Ali
AU  - Dogan, Ali
AU  - Sebik, Ali
PY  - 2011
DA  - February
JF  - Acta Orthopaedica et Traumatologica Turcica
PB  - Turkish Association of Orthopaedics and Traumatology
WT  - DergiPark
SN  - 1017-995X
SP  - 484
EP  - 491
VL  - 44
IS  - 6
LA  - en
AB  - Objectives: The aim of this study was to compare the anti-edema effects of a stable prostacyclin analogue, iloprost, with parenteral and local forms of a non-steroidal anti-inflammatory drug, diclofenac sodium, on traumatic soft tissue edema.Methods: Thirty-two adult male rats were randomly divided into 4 equal groups. Traumatic edema in one paw of each rat was produced by established protocol. Different drugs were then administered to each group: intraperitoneal (i.p.) saline (group 1, control group), topical diclofenac gel (group 2), i.p. diclofenac sodium (group 3), and i.p. iloprost (group 4). The volume of the paws was measured at baseline (before trauma) and at 1 hour, 2 hours, 4 hours, 8 hours, 24 hours, 48 hours, and 72 hours after trauma. The anti-edema effects of these 3 drugs (diclofenac gel, diclofenac sodium i.p., iloprost i.p.) were compared to each other and to the control group.Results: The greatest increase in paw edema in the first, second and fourth hours was seen in the control and iloprost groups. At the 4-hour measurement, edema levels were all equal except control group. Following 4- and 8-hour measurements, edema began to decrease in all groups. After 8 and 24 hours, the fastest decrease in edema was in iloprost group, with complete resolution of edema by 72 hours. The next fastest decrease in paw volume was seen with i.p. diclofenac sodium, followed by diclofenac gel.Conclusion: Iloprost has experimentally higher anti-edema effect than diclofenac sodium for the conservative treatment of the traumatic soft tissue edema.
KW  - Anti-edema effect
KW  - diclofenac sodium
KW  - iloprost
KW  - rat paw volume
KW  - traumatic soft tissue edema
UR  - https://dergipark.org.tr/tr/pub/aott/issue//191933
L1  - https://dergipark.org.tr/tr/download/article-file/169903
L1  - https://dergipark.org.tr/tr/download/article-file/169904
ER  -