TY  - JOUR
T1  - Familial Recurrent  Hydatidiform Moles: A rare case report
TT  - Familial Recurrent Hydatidiform Moles: A rare case report
AU  - Eskicioglu, Fatma
AU  - Kaya, Isin
AU  - Gur, Esra Bahar
AU  - Turan, Guluzar Arzu
PY  - 2014
DA  - September
DO  - 10.17546/msd.80072
JF  - Medical Science and Discovery
JO  - Med Sci Discov
PB  - Zafer AKAN
WT  - DergiPark
SN  - 2148-6832
SP  - 85
EP  - 87
VL  - 1
IS  - 3
LA  - en
AB  - Recurrent hydatidiform moles (RHM) are described as the being of at least two molar pregnancies in the same patient. It is very rare. NLPR7 mutations are found high rate in patients with RHM. KHDC3L is the second responsible gene for RHM. In this paper, we present an interesting case of a familial RHM. Here, we have discussed the genetic counseling to be given to a patient who had been diagnosed as hydatidiform mole in her two previous pregnancies and whose sister had a history of four consecutive molar pregnancies. Because rate of NLPR7 mutation is high in individuals with recurrent molar pregnancy, patients should be recommended to have NLRP7 gene sequence analysis in the first place. If no mutation is detected in this gene, KHDC3l gene sequence analysis should be carried out
KW  - Recurrent hydatidiform moles
KW  - NLPR7
KW  - KHDC3L
KW  - Mutation
CR  - Copyright © 2014 The Author(s); This is an open-access article distributed under the terms of the Creative Commons Attribution
CR  - License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
CR  - provided the original work is properly cited.
UR  - https://doi.org/10.17546/msd.80072
L1  - https://dergipark.org.tr/tr/download/article-file/183858
ER  -