@article{article_209726, title={EFFECT OF PROPOFOL AND MEMANTINE ON ERYTHROCYTE DEFORMABILITY IN DIABETIC RAT MODEL}, journal={Medical Science and Discovery}, volume={2}, pages={221–224}, year={2015}, DOI={10.17546/msd.40291}, author={Kuskonmaz, Serife and Cicek, Erdal and Comu, Faruk and Arslan, Mustafa and Kurtipek, Omer}, keywords={Memantine, propofol, erythrocyte deformability, diabetes mellitus, rat}, abstract={<p> <strong>OBJECTIVES: </strong> In this study we aimed to investigate the effect of diabetes on erythrocyte deformability (ED) and whether it can be changed by an NMDA antagonist propofol or an NMDA agonist, memantine </p> <p> <strong>BACKGROUND: </strong> Several clinical studies showed that ED decreases in diabetes. Recent studies showed that erythrocytes have N-methyl-D-aspartate (NMDA) receptors (NMDA Rec) on their membrane. </p> <p> <strong>METHODS: </strong> Thirty rats were allocated to five groups containing 6 rats each. Memantine was given for 30 days to diabetic rats in one group (group DM) single dose propofol injection is added to this regimen in another group (group DP+ memantine) another group received propofol only (group DP). The remaining groups were controls and diabetic controls. ED was measured in each group and compared </p> <p> <strong>RESULTS: </strong> The deformability index was significantly increased in the diabetic rats ( <em>p </em><0.0001). However, it was similar in Group DC and DP ( <em>p </em>=0.551), Group DC and DM ( <em>p </em>=1.000), Group DC and DPM ( <em>p </em>=0.176). </p> <p> <strong>CONCLUSION: </strong> Neither NMDA antagonist propofol nor NMDA agonist memantine affected the altered red cell rheology in diabetic rat model. </p>}, number={3}, publisher={Zafer AKAN}