TY - JOUR T1 - Leser-Trelat Sign Without Malignancy in a Geriatric Patient A Case Report AU - Yıldız, Pinar AU - Sahın, Mehmet AU - Akdere, Gonca PY - 2015 DA - June DO - 10.20515/otd.80300 JF - Osmangazi Tıp Dergisi PB - Eskişehir Osmangazi Üniversitesi WT - DergiPark SN - 1305-4953 VL - 35 IS - 3 LA - tr AB - SUMMARY: Leser-Trélat sign is characterized by the abrupt appearance of multiple seborrheic keratoses, which are often pruritic, usually it is associated with an underlying malignant disease. Here we report a case of 72-year-old healthy woman with Leser-Trélat. She is consulted to dermatology for her rapidly growing lesions over her lower abdominal and suprapubic regions for seven months. She oriented to our clinic for malignity scanning. We were followed for 1 year and not detected any internal cancer. To date, almost all cases of Leser-Trélat sign have been reported in association with an underlying malignancy. It is less known that Leser-Trélat sign can also occur in healthy individuals in the absence of internal malignancy. Leser-Trélat sign of the patients are evaluated for malignancy and the screening of suspect cases is important. A new and rapidly growing seborrheic keratoses; Leser-Trelat sign is important and suspected cases should be screened for malignancy.KEY WORDS: Leser- Trelat Sign, internal malignancy, seborrheic keratosis.ÖZET: Leser- Trelat işareti kaşıntılı çoklu seboreik keratotik lezyonlar olarak tanımlanır ve sıklıkla altında yatan malignitelerle ilşkilidir. Burada 72 yaşında Leser-Trelat işareti olan bir bayan sunduk. Dermatoloji kliniğinden 7 ayda karın alt kadranda ve suprapubik alanda hızla büyüyen lezyonlarla konsülte edildi. Kliniğimizde malignite tarandı. Bir yıllık takibimizde herhangi bir malignite tespit edilemedi. Bugüne kadar, Leser-Trélat işareti hemen hemen tüm durumlarda altta yatan bir malignite ile birlikte bildirilmiştir. Daha az bilinen ise Leser Trelat işaretinin malignite olmadan da görülebileceğidir. Yeni ve hızla çoğalan seboreik keratoz; Leser-Trelat işareti önemlidir ve şüpheli vakalar malignite açısından taranmalıdır.ANAHTAR KELİMELER: Leser-Trelat Sign, malignite, seboreik keratoz KW - ANAHTAR KELİMELER: Leser-Trelat Sign KW - malignite KW - seboreik keratoz CR - Sneddon, I. B. Roberts, J. B. (1962). An incomplete from of acanthosis nigricans. Gut. 3, 269-72. CR - Hollander, E. V. (1900). Beitrage zur Fruhdiagnose des Darmcarcinomas (Hereditatsverhaltnisse Hautveranderungen) Wochenschr. 26, 483-85. und Med Dtsch CR - Schwartz, R.A. (1996). Sign of Leser- Trélat. J Am Acad Dermatol.35, 88-95. CR - Ponti, G. Luppi, G. Losi, L. Giannetti, A. Seidenari S. (2010). Leser-Trélat syndrome in patients affected by six multiple cancers. J Hematol Oncol. 3,2. primitive CR - Baron, L. A. Prendiville, J. S. (1992). The sign of Leser- Trelat in a young woman with osteogenic sarcoma. J Am Acad Dermatol. 26, 344-47 CR - Heaphy, M. R. Jr, Millns, J. L. Schroeter, A. L. (2000). The sign of Leser-Trélat adenocarcinoma of the lung. J Am Acad Dermatol. 43, 386-390. of CR - Ellis, D. L. Kafka, S. P. Chow, J. C. Nanney, L. B. Inman, W. H. Mc Cadden, M. E. King, L. E. (1987). Jr. Melanoma, growth factors, acanthosis nigricans, the sign of Leser-Trelat, and multipl acrochordons: a possible role of alpha-transforming growth factor in cutaneous paraneoplastic syndromes. N Engl J Med.317,1582- 87. CR - Hafner, C. Vogt, T. (2008). Seborrheic keratosis. J Dtsch Dermatol Ges. 6, 664-77. CR - Gallagher, E. J. LeRoith, D. (2010). The proliferating role of insülin and insülin- like growth factors in cancer. Trends Endocrinol Metab. 21, 610-18. CR - İnamadar, A. C. Palit, A. (2003). Eruptive seborrkoeic keratosis in human infection: a coinsidence or ‘the sign of Leser Trelat’ Br J Dermatol. 149, 435- 36. virus UR - https://doi.org/10.20515/otd.80300 L1 - https://dergipark.org.tr/tr/download/article-file/190594 ER -