TY  - JOUR
T1  - Menstruel Siklus Sırasında Fallop Tüplerinde Lüteinizan Hormon ve Seks Steroid Hormon Reseptörlerinin Ekspresyonu (The Expressions of Luteinizing Hormone and Sex Steroid Hormone Receptors in Human Fallopian Tube During the Menstrual Cycle)
AU  - Kaygusuz, Ecmel
AU  - Çetiner, Handan
AU  - Cesur, Suna
AU  - Yavuz, Hülya
AU  - Yozgatlıgil, Ceylan
AU  - Ayas, Selçuk
AU  - Sağlıcan, Yeşim
PY  - 2014
DA  - August
DO  - 10.16948/zktb.19203
JF  - Zeynep Kamil Tıp Bülteni
PB  - Zeynep Kamil Kadın ve Çocuk Hastalıkları EAH
WT  - DergiPark
SN  - 1300-7971
SP  - 116
EP  - 123
VL  - 45
IS  - 3
LA  - tr
AB  - Amaç: Luteinizan hormon reseptörleri daha önce tubada gösterilmekle birlikte henüz buradaki rolleri tam olarak bilinmemektedir. Menstruel siklus sırasında kadın genital sistemi östrojen ve progesteronu içeren seks steroidlerinin dalgalanan düzeylerine maruz kalırlar. Biz bu çalışmada Luteinizan hormon, östrojen ve progesteron reseptörlerinin tubada siklik varyasyonlarını araştırdık. Materyal ve Metod: Bu çalışmaya benign nedenlerle opere olan 20 olgu dahil edildi. Menstruel siklusun farklı fazlarına sahip olguların Fallopian tüpleri seçildi. Daha sonra bu tüplere immunohistokimyasal boyama uygulandı.Bulgular: Lüteinizan hormon reseptörlerinin ekspresyonları menstruel siklusun farklı fazlarına göre değişiklik göstermemekteydi. İstatiksel analiz sonuçlarına göre östrojen ve progesteron reseptörü ekspresyonunda fazlar arasında fark izlenmedi. Ama progesteron reseptör boyanma yoğunluğu belirgin olarak lueal fazda folliküler faza göre daha yüksekti. Sonuç: Bu çalışmada Fallop tübündeki Lüteinizan hormon, östrojen ve progesteron reseptör ekspresyonlarının folliküler faz ile luteal faz arasındaki farklılıklarını araştırdık. Bu bilgilerin normal tüp fonksiyonlarını anlamada önemli olduğunu düşünmekteyiz.Anahtar kelimeler: Lüteinizan hormon, fallop tüpü, immunohistokimyaABSTRACTPurpose: Expression of Luteinizing hormone (LH) receptors has been showed in the tuba uterina; but their role in the Fallopian tube is still unknown. During the normal menstrual cycle, female reproductive system is exposed to fluctuating levels of sex steroids, including estrogen and progesterone. In this study, we present the cyclical variations of tubal LH, estro-gen receptors (ER), and progesterone receptors (PR).Material and Methods: Twenty women operated for benign causes were included in this study. Fallopian tubes from the different stages of menstrual cycle were collected. Then these tubes sections were examined using immunohistochemistry. Results: Expression of LH receptor did not change according to phases of menstrual cycle and there is no significant difference between follicular phase and luteal phase groups. Ac-cording to the result of statistically analyzed, there is not a significantly differences between the PR of follicular phase and luteal phase.Conclusion: We report on differences in LHR, SHR expression in the Fallopian tube from cases with follicular phase compared with luteal phase. This information may be important for the understanding of normal tubal function.Key words: Luteinizing hormone, Fallopian tube, immunohistochemistry
KW  - Lüteinizan hormon
KW  - fallop tüpü
KW  - immunohistokimya
N2  - Purpose: Expression of Luteinizing hormone (LH) receptors has been showed in the tuba uterina; but their role in the Fallopian tube is still unknown. During the normal menstrual cycle, female reproductive system is exposed to fluctuating levels of sex steroids, including estrogen and progesterone. In this study, we present the cyclical variations of tubal LH, estro-gen receptors (ER), and progesterone receptors (PR).Material and Methods: Twenty women operated for benign causes were included in this study. Fallopian tubes from the different stages of menstrual cycle were collected. Then these tubes sections were examined using immunohistochemistry.Results: Expression of LH receptor did not change according to phases of menstrual cycle and there is no significant difference between follicular phase and luteal phase groups. Ac-cording to the result of statistically analyzed, there is not a significantly differences between the PR of follicular phase and luteal phase.Conclusion: We report on differences in LHR, SHR expression in the Fallopian tube from cases with follicular phase compared with luteal phase. This information may be important for the understanding of normal tubal function.
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UR  - https://doi.org/10.16948/zktb.19203
L1  - https://dergipark.org.tr/tr/download/article-file/205289
ER  -