@article{article_251004, title={Changes of the Oxidant/Antioxidant Equilibrium in Liver, Brain and Kidney Tissues of Pregnant Rats Exposed to Aroclor1254 (2mg/kg/day) During Pregnancy}, journal={Van Veterinary Journal}, volume={26}, pages={65–69}, year={2015}, author={Doğan, Ayşe and Erişir, Mine}, keywords={Poliklorin bifenil, Oksidatif stres, Gebelik, Antioksidan, Aroclor}, abstract={This study was conducted in order to investigate both oxidant and antioxidant parameters in liver, kidney, and brain tissues of pregnant rats exposed to Aroclor 1254. In the study, rats were divided into two groups, each of which consisted of 10 rats. The first group was the pregnant control group, and the second group was the pregnant Aroclor 1254 (2 mg/kg/day dose of Aroclor 1254 was administered by subcutaneous injection for 20 days). The pregnant rats in each group were anesthetized by using ether anaesthesia method, and their liver, brain, and kidney tissues were resected. Parameter of lipid peroxidation malondialdehyde (MDA), glutathione (GSH) levels as well as glutathione peroxydase (GSH-Px), catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GR), glutathione S- transferase (GST) activities were measured in these tissues. As a result of the study, no statistically significant difference was determined between two groups in terms of parameters analysed in liver, kidney, and brain tissues. This study concluded that since a part of Aroclor 1254 (2 mg/kg), which was administered during pregnancy, was transmitted to the infant via placenta, the amount of Aroclor 1254, left in the body of pregnant rat, was not so effective to create oxidative damage in the pregnant rat. It is thought that the oxidative damage which could occur in the pregnant rats could be determined particularly through an advanced study in which a high dosage of Aroclor 1254 is administered to the pregnant rats}, number={2}, publisher={Van Yüzüncü Yıl Üniversitesi}