TY  - JOUR
TT  - Carboplatin hypersensitivity in children with glial tumors: a report of two cases
AU  - Kazgan, Tuğçe
AU  - İlhan, Aysu
AU  - Durmaz, Cemile
AU  - Yağcı-küpeli, Begül
PY  - 2016
DA  - December
Y2  - 2016
DO  - 10.17826/cutf.254541
JF  - Cukurova Medical Journal
JO  - Cukurova Med J
PB  - Çukurova Üniversitesi
WT  - DergiPark
SN  - 2602-3032
SP  - 796
EP  - 798
VL  - 41
IS  - 4
KW  - karboplatin
KW  - hipersensitivite
N2  - Carboplatin, commonly used chemotherapeutic agent in treatment of pediatric cancers, can cause life-threatening hypersensitivty reactions. Carboplatin hypersensitivity is protocol-specific and associated with repeated doses and prolonged use of the drug. Vincristin and carboplatin combination is used efficiently in treatment of pediatric low-grade gliomas. However, hypersensitivity reactions are frequently observed during usage of this protocol. Desensitization strategies with variable success rates were reported. Failure of these strategies may lead to cessation of carboplatin Here, we report two cases with carboplatin hypersensitivity treated with epinephrine administration, in whom carboplatin was discontinued after hypersensitivity reaction.
CR  - 1.	Hartmann JT, Lipp H. Toxicity of platinum compounds. Expert Opin Pharmacother. 2003;4:889-901.
UR  - https://doi.org/10.17826/cutf.254541
L1  - https://dergipark.org.tr/tr/download/article-file/221319
ER  -