TY - JOUR TT - Histopathological and immunohistochemical characteristics of ventricular ependymoma in a goat AU - Farjanıkısh, Ghasem AU - Khodakaram-taftı, Azizollah PY - 2017 DA - January DO - 10.16988/iuvfd.267285 JF - İstanbul Üniversitesi Veteriner Fakültesi Dergisi JO - iuvfd PB - İstanbul Üniversitesi-Cerrahpaşa WT - DergiPark SN - 0250-2836 SP - 77 EP - 80 VL - 43 IS - 1 KW - Ependymoma KW - goat KW - immunohistochemistry N2 - Ependymomas as primarycentral nervous system neoplasms are occasionally observed in human infantshowever; they are rare in animals. A three-year-old male goat was presentedwith clinical neurological signs. At necropsy, a 3×2×2 cm, bulging, white-grey-to red, soft mass extending into the left lateral ventricle of brain wasobserved. Microscopically, the mass with densely cellular population wasnonencapsulated, mostly containing cuboidal-columnar neoplastic cells withpseudo-rosettes formation. Mitotic figures were rare and malignancy indexeswere not observed. Neoplastic cells were immunohistochemically positive for GlialFibrillary Acidic Protein (GFAP), S-100, and vimentin; however, they did notexpress Cytokeratins. On the basis of the location, histologic andimmunohistochemical findings, the tumor was diagnosed as an ependymoma. CR - Cantile. C., Campani, D., Menicagli, M., Arispici, M., 2002. Pathological and immunohistochemical studies of choroid plexus carcinoma of the dog. Journal of Comparative Pathology 126, 183-193. CR - Carrigan, M.J., Higgins, R.J., Carlson, G.P., Naydan, D.K., 1996. Equine papillary ependymoma. Veterinary Pathology 33, 77-80. CR - Cordy, D.R., 1990. Tumors of the nervous system and eye. In: Meuten, D.J., Tumors in Domestic Animals, 4rd ed. University of California Press, Berkeley, CA, 2008., p. 645. CR - Gilbert, M.R., Ruda, R., Soffietti, R., 2010. Ependymomas in adults. Current Neurology and Neuroscience Reports 10, 240-247. CR - Koestner, A., Higgins, R.J., 2002. Tumors of the nervous system. In: Meuten D.J. (ed.): Tumours in Domestic Animals. 4th ed. Iowa State Press, Iowa. 707-709. CR - McGill, I.S., Wells., G.A., 1993. Neuropathological findings in cattle with clinically suspect but histologically unconfirmed bovine spongiform encephalopathy (BSE). Journal of Comparative Pathology 108, 241-260. CR - McKay, J.S., Targett, M.P., Jeffrey, N.D., 1999. Histological characterisation of an ependymoma in the fourth ventricle of a cat. Journal of Comparative Pathology 120, 105-113. CR - Metellus, P., Guyotat, J., Chinot, O., Durand, A., Barrie, M., Giorgi, R., Jouvet, A., Figarella-Branger, D., 2010. Adult intracranial who grade II ependymomas: long-term outcome and prognostic factor analysis in a series of 114 patients. Neuro-oncology 12, 976-984. CR - Michimae, Y., Morita, T., Sunagawa, Y., Sawada, M., Okamoto, Y., Shimada, A., 2004. Anaplastic ependymoma in the cervical spinal cord of a Maltese dog. Journal of Veterinary Medical Science 66, 1155-1158. CR - Simpson, D.J., Hunt, G.B., Tisdall, P.L.C., Govendir, M., Zaki, S., France, M.P., Malik, R., 1999. Surgical removal of an ependymoma from the third ventricle of a cat. Australian Veterinary Journal 77, 645-648. CR - Vernau, K.M., Higgins, R.J., Bollen, A.W., Jimenez, D.F., Anderson, J.V., Koblik, P.D., LeCouteur, R.A., 2001. Primary canine and feline nervous system tumors: Intraoperative diagnosis using the smear technique. Veterinary Pathology 38, 47-57. CR - Vural, S.A., Besalti, O., Ilhan, F., Ozak, A., Haligur, M., 2006. Ventricular ependymoma in a German Shepherd dog. Veterinary Journal 172, 185-187. CR - Wiestler, O.D., Schiffer, D., Coons, S.W., Prayson, R.A., Rosenblum, M.K. 2000. Ependymoma. In: Kleihues P., Cavenee W.K. (eds.): WHO Classification of Tumors Pathology and Genetics of Tumors of the Nervous System. IARC Press, Lyon, France. pp: 72-76. UR - https://doi.org/10.16988/iuvfd.267285 L1 - https://dergipark.org.tr/tr/download/article-file/233878 ER -