TY  - JOUR
TT  - Comparison between GnRH agonist long protocol and GnRH antagonist protocol in IVF-ICSI-ET cycles of normal ovarian reserve infertile patients
AU  - Başeğmez, Önder
AU  - Ürünsak, İbrahim Ferhat
AU  - Khatib, Ghanim
AU  - Çetin, Cihan
AU  - Sucu, Mete
AU  - Özsürmeli, Mehmet
AU  - Çetin, Turan
PY  - 2017
DA  - March
Y2  - 2016
DO  - 10.17826/cutf.280060
JF  - Cukurova Medical Journal
JO  - Cukurova Med J
PB  - Çukurova Üniversitesi
WT  - DergiPark
SN  - 2602-3032
SP  - 27
EP  - 33
VL  - 42
IS  - 1
KW  - Normal over rezervli infertil hastalar
KW  - IVF-ICSI-ET siklusları
KW  - GnRH agonist uzun protokol
N2  - Purpose: The aim of thisstudy was to compare GnRH agonist long protocol and flexible multidose GnRHantagonist protocol for infertile patients with normal ovarian reserve inIVF-ICSI-ET cycles, on which controlled ovarian stimulation was carried out byusing recombinant FSH.Material and Methods: Medical files belonging to 1765 patients who were subjected tocontrolled ovarian stimulation by using recombinant FSH and afterwards toIVF-ICSI-ET were retrospectively analyzed. A total of 174 patients, 121 withGnRH agonist long protocol and 53 with flexible multidose GnRH antagonistprotocol were included in the study. Stimulation periods, total doses of usedFSH, obtained oocyte counts, fertilization rates, implantation rates, averagevalues of hCG positive rates, clinic pregnancy and discharged newborn rateswere compared between the two groups.Results: Average oftotal stimulation time for GnRH antagonist protocol group was found to be8.57±1.26 days, while it was 9.47±1.56 for the GnRG agonist group. HCG positiverates were 35.8% and 34.7% for the GnRH antagonist group and GnRH agonist grouprespectively. Rates of newborns discharged to home was 28.25% for GnRHantagonist protocol and 27.3% in th other.Conclusion: Flexiblemultidose GnRH antagonist protocol provided shorter stimulation period andrequired less average total FSH dose when compared with the GnRH agonist longprotocol. Besides flexible multidose GnRH antagonist protocol can be said toprovide similar effectiveness with the GnRH agonist long protocol.
CR  - 1.	Barbieri RL. Female infertility. In Strauss FJ, Barbieri RL (eds), Reproductive endocrinology. Pensylvania:Elsevier Inc., 5th ed, 2004;633-68.
CR  - 2.	Garcia-Velasco JA, Isaza V, Vdal C. Human ovarian steroid secretion in vivo: effects of GnRH agonist versus antagonist (cetrorelix). Hum Reprod. 2001;16(12):2533-9.
CR  - 3.	Shapiro DB. An overview of GnRH antagonists in infertility treatments. Introduction. Fertil Steril. 2003;80(1):S1-7.
UR  - https://doi.org/10.17826/cutf.280060
L1  - https://dergipark.org.tr/tr/download/article-file/264862
ER  -