@article{article_280149, title={Effect of mianserin on streptozotocin-induced hyperglycemia and metabolic alterations in rats}, journal={Cukurova Medical Journal}, volume={42}, pages={103–119}, year={2017}, DOI={10.17826/cutf.280149}, author={Can, Özgür Devrim and Üçel, Umut İrfan and Özkay, Ümide Demir and Dikmen, Miriş}, keywords={Diabetes mellitus,HbA1c,metabolik kafes,metformin,mianserin,streptozotosin}, abstract={<p class="z"> <b> <span lang="en-us" xml:lang="en-us">Purpose: </span> </b> <span lang="en-us" xml:lang="en-us"> The aim of this study was to investigate possible effects of
atypical antidepressant mianserin on glycemia levels and metabolic parameters
of normoglycemic and diabetic rats. </span> </p> <p> </p> <p class="z"> <b> <span lang="en-us" xml:lang="en-us">Material and
Methods: </span> </b> <span lang="en-us" xml:lang="en-us"> Effects of mianserin administration on
blood glucose levels in rats were assessed by measuring “fasting blood
glucose”, “glycosylated haemoglobin” levels and conducting the “oral glucose
tolerance test”. Changes in metabolic parameters such as food and water
consumption and urine and faeces excretion were observed using metabolic cages. </span> </p> <p> </p> <p class="z"> <b> <span lang="en-us" xml:lang="en-us">Results: </span> </b> <span lang="en-us" xml:lang="en-us"> Administration of mianserin for 7 and 14 days at doses of 30 and 45
mg/kg significantly reduced the hyperglycemia and elevated HbA1c levels; also
improved hyperglycemia induced polydipsia, polyuria, polyphagia, and increased
faeces amounts. Mianserin, at both of the administrated doses, reduced the
weight loss observed in diabetic animals. With regard to the
anti-hyperglycaemic effect, mianserin administered at a dose of 30 mg/kg was
found to be as effective as the reference drug metformin (dose, 1 g/kg). </span> </p> <p> </p> <p class="z"> <b> <span lang="en-us" style="font-size:10pt;font-family:’Times New Roman’, serif;" xml:lang="en-us">Conclusion: </span> </b> <span lang="en-us" style="font-size:10pt;font-family:’Times New Roman’, serif;" xml:lang="en-us"> This study showed that the anti-hyperglycemic
effect of mianserin, an atypical antidepressant, was comparable to those of the
reference drug metformin. However, the pharmacological mechanisms underlying
this anti-hyperglycemic effect of mianserin remain to be elucidated </span> <br /> </p>}, number={1}, publisher={Çukurova Üniversitesi}