@article{article_282169, title={Cytotoxic and Cytogenetic Effects of Bisphenol-A in Mytilus Galloprovincialis (Lamarck 1819)}, journal={Aquaculture Studies}, volume={17}, pages={93–101}, year={2017}, DOI={10.17693/yunusae.v17i26557.282169}, url={https://izlik.org/JA59HK85DD}, author={Çakal Arslan, Özlem and Parlak, Hatice and Karaaslan, Muhammet Ali and Boyacıoğlu, Meltem}, keywords={Micronukleus Testi,Bisphenol-a,Mytilus galloprovincialis,Genotoksisite}, abstract={<p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:150%;"> <span lang="en-us" style="font-size:14px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Bisphenol-A
(BPA), is one of the most important industrial chemicals synthesized for
diverse applications. The environmental concentrations of BPA are at high risk
level due to use widely in many fields of industry according to the latest
studies. </span> <span lang="en-us" style="font-size:14px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> </span> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> <span style="font-size:14px;">However, less knowledge has been founded to the
toxicity of BPA. No studies have been founded genotoxicity of BPA to the </span> <i> <span style="font-size:14px;">Mytilus galloprovincialis </span> </i> </span> <span lang="en-us" style="font-size:14px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">(Lamarck 1819) </span> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> <span style="font-size:14px;">. The Micronucleus test is a biomarker of
mutagenicity/genotoxicty used for determining changes in DNA fragments exposure
to pollution and chemicals. For this purpose, frequency of MN and other nuclear
abnormalities (binucleated, nuclear buds, fragmented/apoptotic cells) was
analyzed. Increasing concentrations of BPA (12.5-100 µg-BPA/L) were tested for
determination of MN under semi-static conditions in the laboratory. According
to the results of the study, it is revealed that all concentration of BPA
increases the genotoxic damage, and elevates the micronucleus frequency from ‰
11, 33 to ‰ 37, 35 Thus, it was tried to determine whether BPA affected the
cells of </span> <i> <span style="font-size:14px;"> </span> <span style="font-size:14px;">M. galloprovincialis </span> </i> <span style="font-size:14px;"> </span> </span> <span lang="en-us" style="font-size:14px;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">(Lamarck 1819) </span> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us"> <span style="font-size:14px;">at the level of DNA through to the MN assay.  </span> </span> </p> <p> </p> <p> </p>}, number={1}