TY  - JOUR
TT  - Bisfenol- A’ nın Mytilus galloprovincialis (Lamarck 1819) Üzerine Sitotoksik ve Genotoksik Etkileri
AU  - Çakal Arslan, Özlem
AU  - Parlak, Hatice
AU  - Karaaslan, Muhammet Ali
AU  - Boyacıoğlu, Meltem
PY  - 2017
DA  - February
DO  - 10.17693/yunusae.v17i26557.282169
JF  - Aquaculture Studies
JO  - AquaST
PB  - Su Ürünleri Merkez Araştırma Enstitüsü
WT  - DergiPark
SN  - 2618-6381
SP  - 93
EP  - 101
VL  - 17
IS  - 1
KW  - Micronucleus Assay
KW  - Bisphenol-a
KW  - Mytilus galloprovincialis
KW  - Genotoxicity
N2  - Bisfenol-A (BPA), çeşitli uygulamalar içinsentezlenen önemli endüstriyel kimyasallardan biridir. En son çalışmalara göresanayinin birçok alanında yaygın kullanımı nedeniyle BPA’ nın çevreselkonsantrasyonları yüksek risk düzeyinde bulunmaktadır. BPA’ nın Mytilus galloprovincialis (Lamarck 1819) üzerine genotoksisitesinin belirlendiği çalışmabulunmamaktadır. Mikronukleusdenemeleri, interfaz hücrelerin sitoplazmasında ki DNA parçacıklarınındeğişimine neden olan kimyasalların ve kirliliğin belirlenmesinde kullanılanmutajenite test sistemidir. Bu amaçla, micronukleus (MN) ve diğer çekirdekanormallikleri (nuklear bud, binukleus, apoptatcik çekirdek) incelenmiştir.Midyeler BPA’ nın (12.5-100 µg-BPA/L) artan konsantrasyonlarısemi-statik labaratuvar şartlarında maruz bırakılmışlardır. Çalışmanınsonuçlarına göre; BPA’ nın tüm konsantrasyonları genotoxic hasarı arttırmaktave ‰ 11, 33 to ‰ 37, 35 MN oluşumuna neden olduğu gözlenmiştir. Bu nedenle, MNtesti ile BPA’ nın DNA düzeyinde, M. galloprovincialis'in hücreleri etkileyip etkilemediğini belirlenmeye çalışılmıştır.
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UR  - https://doi.org/10.17693/yunusae.v17i26557.282169
L1  - https://dergipark.org.tr/tr/download/article-file/304988
ER  -