TY  - JOUR
TT  - Short stature, insufficient annual height growth and back bone age: Nutritional growth retardation or growth hormone deficiency?
AU  - Balcı Sezer, Oya
AU  - Buluş, Derya
PY  - 2016
DA  - December
Y2  - 2016
DO  - 10.16899/ctd.30784
JF  - Çağdaş Tıp Dergisi
JO  - J Contemp Med
PB  - Rabia YILMAZ
WT  - DergiPark
SN  - 2146-6009
SP  - 277
EP  - 282
VL  - 6
IS  - 4
KW  - Boy kısalığı
KW  - İnsülin benzeri growth faktörü 1
KW  - malnutrisyon
KW  - çocuk
N2  - Background/Aim: Serum insulin-like growth factor 1 (IGF-1) concentrations are affected both by nutritional status and serum growth hormone levels therefore IGF-1 is useful as an indicator of growth and nutritional status. The aim of this study is to determine the cut off level of IGF-1 to differentiate nutritional growth retardation (NGR) from growth hormone deficiency (GHD) in children with insufficient annual height growth and back bone age.Methods: The study group included 57 children who had been diagnosed with NGR due to malnutrition and 36 children with similar age and sex, who had been diagnosed with short stature due to GHD. Serum free IGF-1 concentrations were determined by chemiluminescent immunometric assay in all children.Results: There was no significant difference in serum IGF-1 levels between NGR and GHD groups. We could not find an IGF-1 cut off level to differentiate NGR from GHD in children with NGR.Conclusion: We suggest that examination of IGF-1 levels in children with NGR to exclude GHD is not useful.
CR  - Grummer-Strawn LM, Reinold C, Krebs NF. Use of World Health Organization and CDC growth charts for children aged 0-59 months in the United States. MMWR Recomm Rep 2010;59 :1-15.
CR  - Cooke DW, Divall SA, Radovick S. Normal and aberrant growth. In: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams text- book of endocrinology. 12th ed. Philadelphia (PA): Saunders Elsevier; 2011. p. 935-1053.
UR  - https://doi.org/10.16899/ctd.30784
L1  - https://dergipark.org.tr/tr/download/article-file/264605
ER  -