TY  - JOUR
TT  - A Nutrigenetic Overview to Human Health: Single Nucleotide Polymorphisms in Fatty Acid Desaturase (FADS) Encoding Genes
AU  - Tekiner, İsmail Hakkı
AU  - Şengül, Nuray
AU  - Varlı, Bakiye Nur
AU  - Kestir, Elif
AU  - Mehdizadeh Tapeh, Leila
AU  - Kaya, Simge
PY  - 2017
DA  - April
Y2  - 2017
JF  - İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi
JO  - IGUSABDER
PB  - İstanbul Gelişim Üniversitesi
WT  - DergiPark
SN  - 2536-4499
SP  - 49
EP  - 58
IS  - 1
KW  - Desatüraz
KW  - FADS geni
KW  - Yağ asiti
KW  - Sağlık
KW  - Nütrigenetik
N2  - Long-chain polyunsaturated fatty acids (LC-PUFAs) play animportant role in some physiological processes in the human body. Their leveland composition are highly dependent on their intake in the diet or on theintake of fatty acid (FA) precursors. The fatty acid precursors areendogenously elongated and desaturated to physiologically active LC-PUFAs bythe fatty acid desaturases (FADS), encoded by FADS gene cluster. The singlenucleotide polymorphisms (SNPs) in these genes are highly associated with theconcentration of ω3- and ω6-fatty acids. Beside nutrition, genetic factors alsoplay an important role in the regulation of LC-PUFAs. Changes in desaturaseactivity have potentially large impacts on cellular FA content, whichconsequently influences numerous biological processes. A genetic variation inthe LC-PUFA biosynthetic pathway, especially within the FADS gene cluster,determines the levels of circulating and tissue PUFAs and several biomarkers. Inthis review, we aimed to provide an nutrigenetic overview to the human healthover single nucleotide polymorphisms in the fatty acid desaturase (FADS)encoding genes.
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UR  - http://dergipark.org.tr/tr/pub/igusabder/issue//286202
L1  - http://dergipark.org.tr/tr/download/article-file/268867
ER  -