@article{article_288777, title={Dapsone Induced Aplastic Anemia / Dapson Kaynaklı Aplastik Anemi}, journal={Osmangazi Tıp Dergisi}, volume={39}, pages={90–93}, year={2017}, DOI={10.20515/otd.288777}, author={Üsküdar Teke, Hava and Karakükcü, Çiğdem and Uğur, Hediye and Tokmak, Salih and Ünal, Ali}, keywords={Dapsone,aplastic anemia}, abstract={<p class="MsoNormal" style="margin-top:0cm;margin-right:14.1pt;margin-bottom:.0001pt;margin-left:14.2pt;text-align:justify;line-height:normal;"> <span style="font-size:14px;font-family:’Times New Roman’, serif;">ABSTRACT: </span> <span style="font-size:14px;font-family:’Times New Roman’, serif;"> </span> <span lang="en-us" style="font-size:10pt;font-family:’Times New Roman’, serif;" xml:lang="en-us"> <span style="font-size:14px;">Dapsone is a sulfone antibiotic, which has
anti-inflammatory and anti-bacterial effects and used in leprosy, intractable
skin lesions, rheumatologic diseases like systemic lupus erythematosus and </span> <i> <span style="font-size:14px;">Pneumocystis jiroveci </span> </i> <span style="font-size:14px;"> prophylaxis.
Aplastic anemia is an uncommon adverse hematologic effect in patients treated
with dapsone. We present a 59 years old female patient which developed aplastic
anemia, direct coombs positively and methemoglobinemia because of dapsone.
Before starting dapsone treatment, side effect profile must be discussed
thoroughly; periodic CBC must be performed before and after the treatment, even
without any patient complaints. </span> </span> </p> <p> </p> <p class="MsoNormal" style="margin-top:0cm;margin-right:14.1pt;margin-bottom:.0001pt;margin-left:14.2pt;text-align:justify;line-height:normal;"> <span style="font-size:14px;font-family:’Times New Roman’, serif;">KEYWORDS: </span> <span lang="en-us" style="font-size:14px;font-family:’Times New Roman’, serif;" xml:lang="en-us">Dapsone, aplastic anemia, hemolysis </span> </p> <p class="MsoNormal" style="margin-top:0cm;margin-right:14.1pt;margin-bottom:.0001pt;margin-left:14.2pt;text-align:justify;line-height:normal;"> <span lang="en-us" style="font-size:10pt;font-family:’Times New Roman’, serif;" xml:lang="en-us"> <br /> </span> </p> <p class="MsoNormal" style="margin-top:0cm;margin-right:14.1pt;margin-bottom:.0001pt;margin-left:14.2pt;text-align:justify;line-height:normal;"> <span style="font-size:14px;font-family:’Times New Roman’, serif;">ÖZET: </span> <span lang="en-us" style="font-size:10pt;font-family:’Times New Roman’, serif;" xml:lang="en-us"> <span style="font-size:14px;">Dapsone, romatolojik hastalıklardan sistemik lupus
eritematozis ve </span> <i> <span style="font-size:14px;">Pneumocystis jiroveci
proflaksisi </span> </i> <span style="font-size:14px;">ile lepra ve inatçı cilt lezyonlarında kullanılan,
anti-inflamatuvar ve antibakteriyel özelliklere sahip bir sülfon
antibiyotiktir. Aplastik anemi, dapsonla tedavi edilen hastalarda nadir görülen
hematolojik bir yan etkidir. Bu yazıda dapsona bağlı aplastik anemi, direkt
coombs pozitifliği ve methemoglobinemi gelişen 59 yaşındaki kadın hastayı
sunduk. Dapson başlamadan önce ilacın yan etkileri dikkatli bir şekilde gözden
geçirilmeli, ilacı başlamadan önce ve başladıktan sonra periyodik olarak tam
kan sayımı yapılmalıdır. </span> <b> </b> </span> </p> <p> <b> </b> </p> <b> </b> <p class="MsoNormal" style="margin-top:0cm;margin-right:-21.35pt;margin-bottom:.0001pt;margin-left:0cm;text-align:justify;line-height:normal;"> <span style="font-size:14px;"> </span> </p> <p class="MsoNormal" style="margin-top:0cm;margin-right:14.1pt;margin-bottom:.0001pt;margin-left:14.2pt;text-align:justify;line-height:normal;"> <span style="font-size:14px;font-family:’Times New Roman’, serif;">ANAHTAR KELİMELER: </span> <span style="font-size:14px;font-family:’Times New Roman’, serif;"> </span> <span lang="en-us" style="font-size:14px;font-family:’Times New Roman’, serif;" xml:lang="en-us">Dapson, aplastik anemi, hemoliz </span> <span style="font-size:10pt;font-family:’Times New Roman’, serif;"> </span> </p> <p> </p>}, number={1}, publisher={Eskişehir Osmangazi Üniversitesi}