@article{article_289407, title={Evaluation of mortality related factors in peptic ulcer perforation: Retrospective case-control study}, journal={Archives of Clinical and Experimental Medicine}, volume={1}, pages={1–3}, year={2016}, DOI={10.25000/acem.289407}, author={Topcu, Ahmet and Kıvanç, Ali Ediz and Kudaş, İlyas and Şişik, Abdullah and Özel, Yahya and Acar, Aylin and Başak, Fatih and Ezberci, Fikret}, keywords={Akut batın,Peptik Ülser,Mortalite}, abstract={<p class="MsoNormal" style="line-height:200%;"> <span style="font-size:12pt;line-height:200%;">Aim: Although there has been significant
progress in current medical treatments for the treatment of peptic ulcer, there
has been no change in the incidence of peptic ulcer perforation (PUP). PUP has
an important place in urgent surgery due to mortality rates. In this study, it
was aimed to determine the factors related to death related to PUP. </span> </p> <p> </p> <p class="MsoNormal" style="line-height:200%;"> <span style="font-size:12pt;line-height:200%;">Material and method: Observational type
study was planned. Patients who underwent surgery due to PUP in 2009-2016 included
to study. The number of samples was set at 225 to show 30% difference with a 5%
α error at 90% safety interval. Twenty patients were added to reduce the error.
Patients were screened for demographic data, presence of chronic disease
(diabetes, cardiac), smoking status, nonsteroidal anti-inflammatory (NSAID)
use, reference leukocyte level, complaint-to-intervention time and surgical site
infection (SSI). The death in the perioperative period (first month) was
determined as the main outcome parameter. Patients were divided into two groups
according to the presence of death (Group 1: study group, Group 2: control
group). Descriptive statistics, number, percentage, mean ± standard deviation,
median (quartile range) were used for statistics. T-test, Mann-Whitney,
Fisher’s exact and Chi-square test  were
used for comparisons. A p value of less than 0.05 was considered significant at
95% safety interval. </span> </p> <p> </p> <p class="MsoNormal" style="line-height:200%;"> <span style="font-size:12pt;line-height:200%;">Results:  </span> <span style="font-size:12pt;">245 patients (group 1: 11 (4.5%), group
2: 234 (95.5%) were included in the study. The groups were divided into two
groups according to sex (group 1: Male/Female=1,2, group 2: Male/Female=6,1)
and age (group 1: 62,8±16,6, group 2: 40±16,8) The difference was detected
(p=0.016, p=0.0001). Chronic cardiac diseases were more common in the study
group (p=0.0001). There was no difference in the presence of diabetes, smoking,
and NSAID use (p=0.092, p=0.624, p=0.214). Leukocyte levels were found to be
low in the study group (group 1: 9 (10) thousand/mm3, group 2: 13 (6),
p=0.032). Complaints-operation times were higher in the study group (group 1:
12 (14) hours, group 2: 4 (4), p=0.0001). All the patients were repaired by
Graham Rapha and drained. The duration of post-operative stay was similar
between the groups (group 1: 4 (5) days, group 2: 5 (2), p=0.443). SSI was more
frequent in the study group (p=0.008). Conclusion: Patients with female gender,
advanced age, and chronic heart disease should be more cautious due to the high
mortality risk. </span> </p>}, number={1}, publisher={Mustafa HASBAHÇECİ}