TY  - JOUR
TT  - Evaluation of mortality related factors in peptic ulcer perforation: Retrospective case-control study
AU  - Topcu, Ahmet
AU  - Kıvanç, Ali Ediz
AU  - Kudaş, İlyas
AU  - Şişik, Abdullah
AU  - Özel, Yahya
AU  - Acar, Aylin
AU  - Başak, Fatih
AU  - Ezberci, Fikret
PY  - 2016
DA  - December
DO  - 10.25000/acem.289407
JF  - Archives of Clinical and Experimental Medicine
JO  - Arch Clin Exp Med
PB  - Mustafa HASBAHÇECİ
WT  - DergiPark
SN  - 2564-6567
SP  - 1
EP  - 3
VL  - 1
IS  - 1
KW  - Akut batın
KW  - Peptik Ülser
KW  - Mortalite
N2  - Aim: Although there has been significantprogress in current medical treatments for the treatment of peptic ulcer, therehas been no change in the incidence of peptic ulcer perforation (PUP). PUP hasan important place in urgent surgery due to mortality rates. In this study, itwas aimed to determine the factors related to death related to PUP. Material and method: Observational typestudy was planned. Patients who underwent surgery due to PUP in 2009-2016 includedto study. The number of samples was set at 225 to show 30% difference with a 5%α error at 90% safety interval. Twenty patients were added to reduce the error.Patients were screened for demographic data, presence of chronic disease(diabetes, cardiac), smoking status, nonsteroidal anti-inflammatory (NSAID)use, reference leukocyte level, complaint-to-intervention time and surgical siteinfection (SSI). The death in the perioperative period (first month) wasdetermined as the main outcome parameter. Patients were divided into two groupsaccording to the presence of death (Group 1: study group, Group 2: controlgroup). Descriptive statistics, number, percentage, mean ± standard deviation,median (quartile range) were used for statistics. T-test, Mann-Whitney,Fisher's exact and Chi-square test wereused for comparisons. A p value of less than 0.05 was considered significant at95% safety interval. Results:245 patients (group 1: 11 (4.5%), group2: 234 (95.5%) were included in the study. The groups were divided into twogroups according to sex (group 1: Male/Female=1,2, group 2: Male/Female=6,1)and age (group 1: 62,8±16,6, group 2: 40±16,8) The difference was detected(p=0.016, p=0.0001). Chronic cardiac diseases were more common in the studygroup (p=0.0001). There was no difference in the presence of diabetes, smoking,and NSAID use (p=0.092, p=0.624, p=0.214). Leukocyte levels were found to below in the study group (group 1: 9 (10) thousand/mm3, group 2: 13 (6),p=0.032). Complaints-operation times were higher in the study group (group 1:12 (14) hours, group 2: 4 (4), p=0.0001). All the patients were repaired byGraham Rapha and drained. The duration of post-operative stay was similarbetween the groups (group 1: 4 (5) days, group 2: 5 (2), p=0.443). SSI was morefrequent in the study group (p=0.008). Conclusion: Patients with female gender,advanced age, and chronic heart disease should be more cautious due to the highmortality risk.
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UR  - https://doi.org/10.25000/acem.289407
L1  - https://dergipark.org.tr/tr/download/article-file/277951
ER  -