@article{article_297910, title={Evaluation of single nucleotide polymorphisms of angiotensin II type 2 receptor (AGTR2) gene and interleukin 4 (IL-4) gene for their contribution to the risk of preeclampsia in Turkish population}, journal={Cukurova Medical Journal}, volume={42}, pages={477–483}, year={2017}, DOI={10.17826/cutf.297910}, author={Özpak, Lütfiye and Pazarbaşı, Ayfer and Keser, Nurşen and Yılmaz, M. Bertan and Lüleyap, H. Ümit and Özgünen, Fatime Tuncay}, keywords={IL-4,Preeklampsi,AGTR2,polimorfizm.}, abstract={Purpose: Preeclampsia, specific to human pregnancies, is a serious disorder, which occurs approximately in 6-10% of all pregnancies. It is a complex disorder, in which immune and genetic factors also take part. The aim of the current study was toinvestigate whether there is an association between AGTR2 A1675G and IL4 -590 (C>T) polymorphisms and preeclampsia. Material and Methods: Genomic DNA was extracted from the peripheral venous blood of 131 preeclamptic and 86 normotensive pregnant women. The AGTR2 and IL-4 polymorphisms were genotyped by using a polymerase chain reaction assay. Results: As for AGTR2 gene 1675 polymorphism, there was not any significant difference in terms of genotype frequencies but there was a significant difference in terms of allele frequencies. As for IL-4 gene -590 polymorphism, there was not any significant difference in terms of genotype and allele frequencies. Conclusions: AGTR2, GG genotype and IL-4, TT genotype were found significantly higher in preeclamptic women than normotensive pregnant women.These genotypes might be a susceptibility risk factor for preeclampsia but these findings need to be tested in a larger sample size. <div> </div> }, number={3}, publisher={Çukurova Üniversitesi}