TY  - JOUR
TT  - Çocukluk çağı obezitesinin kardiyak yapı ve fonksiyonlara etkisi
AU  - Atik, Fatih
AU  - Şanlı, Cihan
AU  - Törel Ergür, Ayça
AU  - Alpcan, Ayşegül
PY  - 2017
DA  - March
DO  - 10.18663/tjcl.297946
JF  - Turkish Journal of Clinics and Laboratory
JO  - TJCL
PB  - DNT Ortadoğu Yayıncılık A.Ş.
WT  - DergiPark
SN  - 2149-8296
SP  - 6
EP  - 10
VL  - 8
IS  - 1
KW  - Pediatric obesity
KW  - ventricular dysfunction
KW  - echocardiography
N2  - Amaç:Bu çalışmada nonkomplike obez ve obez olmayançocuklarda sol ventrikül yapı ve fonksiyonların karşılaştırılması amaçlandı.Gereçve Yöntemler: 40 sağlıklı obez olmayan ve obezitenin komplikasyonu(hipertansiyon, hiperkolesterolemi vs) veya başka bir hastalığı olmayan 40 obez çocukta kardiyakgeometrinin antropometik ve konvansiyonel ekokardiyografik parametreleri ve solventrikül fonksiyonu elde edildi. Açlık plazma glukozu ve insülini bakılıpinsülin direnç parametresi (HOMA-IR) hesaplandı.Bulgular:Boy, ağırlık, vücut yüzey alanı, vücut kitle indeksiobez grupta anlamlı olarak yüksek tespit edildi (P < 0,001). İnsülin veHOMA-IR obez grupta yüksekti. Sol ventrikül sistolik ve diyastolik çaplarıarasında fark tespit edilmedi (P ˃ 0,05). Solventrikülkitlesi (LVM), LVM/ht, LVM/BMI, rölatif duvarkalınlığı (RWT), obez çocuklarda kontrol grubuna göre oldukça artmıştı (P <0,001) ve bunların da en önemli olanıekzantrik sol ventrikül hipertrofisiydi. Ejeksiyon fraksiyon belirgin olarakazalmıştı. BMI, LV posterior duvar kalınlığı ve interventriküler septalkalınlık arasında belirgin korelasyon görüldü (R > 0,45, P < 0,05).İnsülin rezistan obez grupta hipertrofinin her iki tipi de görüldü.Sonuçlar: Değişen homeostatik ve nörohumoral mekanizmaların, yüksek metabolik ihtiyacın kompansasyonunun artmışsol ventrikül kitlesi, azalmış myokardiyal performans hemodinamik yük sebebiolduğu, bunun da yüksek kardiyovasküler morbidite ve mortalite oranları ileilişkili olduğu biliniyor. Değişmiş homeostatik ve nörohumoral mekanizmalar,artmış metabolik gereksinimler, artmış ventriküler kitle, azalmış myokardiyalperformans hemodinamik yol ile ilişkili olarak kardiyovasküler morbidite vemortalite oranlarını artırmaktadır.
CR  - McCrindle BW. Cardiovascular Consequences of Childhood Obesity. Can J Cardiol 2015; 31: 124-130.
CR  - Karuparthi PR, Yerram P, Govindarajan G, Hayden MR. Obesity and Cardiovascular Risk. Current Cardiovascular Risk Reports 2008; 2:113-9.
CR  - Chinalli M, de Simone G, Roman MJ, et al.  Impact of Obesity on Cardiac Geometry and Function in a Population of Adolescents. The Strong Heart Study.  J Am Coll Cardiol 2006; 47: 2267-73.
CR  - Maron BJ, Thompson PD, Ackerman MJ, et al. American Heart Association Council on Nutrition, Physical Activity, and Metabolism. Circulation. 2007; 115: 1643-55.
CR  - Zeybek C, Celebi A, Aktuglu, Zeybek C, et al. The Effect of Low Carbohydrate Diet on Left Ventricular Diastolic Function in obese children. Pediatr Int 2010; 52: 218-23.
CR  - Freedman D, Dietz W, Srinivasan S, Berenson G. The relation of overweight to cardiovascular risk factors among children and adolescents: The Bogalusa heart study. Pediatrics 1999; 103:1175‐82.
CR  - Pascual M, Pascual DA, Soria F et al. Effects of isolated obesity on systolic and diastolic left ventricular function. Heart 2003; 10:1152-6.
CR  - Weiss R, Dziura J, Burgert TS, et al. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 2004, 350: 2363-74.
CR  - Messerli FH. Cardiovascular effects of obesity and hypertension. Lancet 1982; 1:1165-8.
CR  - Ku CS, Lin SL, Wang DJ, Chang SK, Lee WJ. Left ventricular filling in young normotensive obese adults. Am J Cardiol 1994; 8: 613-5.
CR  - Ozturk A, Mazicioglu MM, Hatipoglu N et al. Reference body mass index curves for Turkish children 6 to 18 years of age. J Pediatr Endocrinol Metab 2008; 9: 827-36.
CR  - Kuczmarski RJ, Ogden CL, Guo SS, et al. 2000 CDC growth charts for the United States: methods and development. Vital Health Stat 2002; 246: 1-190.
CR  - Conwell LS, Trost SG, Brown WJ, Batch JA. Indexes of insulin resistance and secretion in obese children and adolescents. Diabetes Care. 2004; 27: 314-9.
CR  - Sahn DJ, DeMaria A, Kisslo J, Weyman A. Recommendations regarding quantitation in M mode echocardiography: Results of a survey of echocardiographic measurements. Circulation 1978; 58: 1072-83.
CR  - Teicholz LE, Cohen MV, Sonnenblick BM, Gorlin R. Study of left ventricular geometry and function by Biscan ultrasonography in patients with and without asynergy. N Engl J Med 1964; 291:120-8.
CR  - Devereux RB, Alonso DR, Lutas EM, et al. Echocardiographic assessment of left ventricular hypertrophy-comparison to necropsy findings. Am J Cardiol 1987; 56: 450-8.
CR  - Daniels SR, Meyer RA, Liang YC, Bove KE. Echocardiographically determined left ventricular mass index in normal children, adolescents and young adults. J Am Coll Cardiol 1988; 12: 703-8.
CR  - Schiller NB, Shah PM, Crawford M, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. J Am Soc Echocardiogr 1989; 2: 358-67.
CR  - Williams CL, Hayman LL, Daniels SR, et al. Cardiovascular health in childhood: a statement for health professionals from the Committee on Atherosclerosis, Hypertension, and Obesity in the Young (AHOY) of the Council on Cardiovascular Disease in the Young, American Heart Association. Circulation 2002; 106: 143-60.
CR  - Hirschler V, Acebo HLP, Fernandez GB Gonzalez C, Jadzinsky M. The influence of obesity and, insulin resistance on left atrial size in children. Pediatric Diabetes 2006; 7: 39-44.
CR  - Peterson LR, Waggoner AD, Schechtman KB, et al. Alterations in left ventricular structure and function in young healthy obese women, assesment by echocardiography and tissue doppler imaging. J Am Coll Cardiol. 2004; 43:1399-404.
CR  - Koch R, Sharma AM. Obesity and Cardiovascular Hemodynamic Function. Current Hypertension Reports 1999; 1:127-130.
CR  - Movahed MR, Saito Y. Lack of Association between Obesity and Left Ventricular Systolic Dysfunction. Echocardıography 2009; 26: 128-132.
CR  - Berkalp B, Cesur V, Corapcioglu D, Erol C, Baskal N. Obesity and left ventricular diastolic dysfunction. Int J Cardiol 1995; 1: 23-6.
CR  - Chiarelli F, Marcovecchio ML. Insulin resistance and obesity in childhood. Eur J Endocrinol 2008; 159: 67-74.
CR  - Masugata H, Senda S, Goda F et al. Left ventricular diastolic dysfunction as assessed byechocardiography in metabolic syndrome. Hypertens Res 2006; 11: 897-903.
CR  - De Simone G, Devereux RB, Daniels SR, et al. Stroke volume and cardiac output in normotensive children and adults. Assessment of relations with body size and impact of overweight. Circulation 1997, 95: 1837-43.
CR  - Kenchaiah S, Evans JC, Levy D, et al. Obesity and the risk of heart failure. N Engl J Med 2002; 347: 305-13.
CR  - Dorbala S, Crugnale S, Yang D, et al. Effect of body mass index on left ventricular cavity size and ejection fraction. Am J Cardiol 2006; 97: 725-9.
CR  - Wong CY, O’Moore-Sullivan T, Leano R, et al. Alterations of left ventricular myocardial characteristics associated with obesity. Circulation 2004; 110: 3081-7.
CR  - Tumuklu MM, Etikan I, Kisacik B, Kayikcioglu M. Effect of obesity on left ventricular structure and myocardial systolic function: Assesment by tissue doppler imaging and strain/strain rate imaging. Echocardiography 2007; 24: 802-9.
UR  - https://doi.org/10.18663/tjcl.297946
L1  - https://dergipark.org.tr/tr/download/article-file/283526
ER  -