TY  - JOUR
TT  - EVALUATION OF STYRENE INDUCED OXIDATIVE STRESS WITH DYNAMIC DISULFIDE/THIOL HOMEOSTASIS
AU  - Bal, Ceylan
AU  - Çetıntepe, Sultan Pınar
AU  - Gündüzöz, Meşide
AU  - Erdoğan, Serpil
AU  - Alışık, Murat
AU  - Yılmaz, Ömer Hınç
AU  - Tutkun, Engin
AU  - Erel, Özcan
PY  - 2017
DA  - February
JF  - The Turkish Journal Of Occupational / Environmental Medicine and Safety
JO  - turjoem
PB  - Engin TUTKUN
WT  - DergiPark
SN  - 2149-4711
SP  - 40
EP  - 40
VL  - Volume 2
IS  - İssue 1 (1)
KW  - EVALUATION OF STYRENE INDUCED OXIDATIVE STRESS WITH DYNAMIC DISULFIDE/THIOL HOMEOSTASIS
N2  - Styrene is the predominantsolvent used in printer. It is a colorless and volatile aromatic hydrocarbonwith an original smell. Main accused toxic substance for styrene inducedoxidative stress is styrene-7,8-oxide. Phenylglyoxylic acid (PGA) and mandelicacid (MA) are the basic metabolites that are used for sytrene exposurescreening. In this study we aimed to investigate the association betweenstyrene metabolites and dynamic disulfide/thiolhomeostasis in people working in a printing center. 30 non-smoker, inkjet printing workers, included as thestudy subjects. 30 non-smokers with no exposure were recruited as the controlgroup. The study was approved by the local ethic committee. We used Erel and Neşelioğlu’s method for serum disulfide/thiol homeostasismeasurements. PGA, MA, hippuric acid, methyl hippuric acid levels were detected byhigh-performance liquid chromatography usingsame commercial kit. Phenol levels detected with a commercial kit (Eureka, Italy), too Theurinary PGA+MA, hippuric acids and phenol values of worker group weresignificantly higher than the control group (p<0.001, p=0.001 and p=0.001,respectively). There wasn’t any significant difference in terms of methyl hippuric acid between groups (p=0.101). Serumdisulfide levels, disulfide /native thiol ratios anddisulfide/total thiol ratios of exposed group were significantly higher thancontrol group while native thiol/total thiol ratio was significantly lower(p<0.001).With this study we, forthe first time demonstrate that the breakdown of tiol-disulfiide balance inhuman body by styrene exposure. Disulfide/thiol homeostasis measurements can be auseful and reliable marker for oxidative stress caused by styrene exposure.
CR  - Department of Biochemistry, Yıldırım Beyazıt University, Ankara, Turkey
CR  - Department of Internal Medicine, Hacettepe University, Ankara, Turkey
CR  - Department of Family Medicine, Occupational Diseases Hospital, Ankara, Turkey
CR  - Department of Biochemistry, Atatürk Educational and Research Hospital, Ankara, Turkey
CR  - Department of Toxicology, Occupational Diseases Hospital, Ankara, Turkey
UR  - https://dergipark.org.tr/tr/pub/turjoem/issue//303831
L1  - https://dergipark.org.tr/tr/download/article-file/290803
ER  -