TY  - JOUR
TT  - THE PROTECTIVE ROLE OF ERDOSTEINE AGAINST CYCLOSPORINE A- INDUCED TESTICULAR TOXICITY
AU  - Nacar, Emel
AU  - Sak, Zafer
AU  - Motor, Sedat
AU  - Gurpinar, Ahmet Burak
AU  - Ecevit, Hasret
AU  - Sefil, Nebahat Kaplan
AU  - Ozturk, Oktay Hasan
PY  - 2017
DA  - February
JF  - The Turkish Journal Of Occupational / Environmental Medicine and Safety
JO  - turjoem
PB  - Engin TUTKUN
WT  - DergiPark
SN  - 2149-4711
SP  - 45
EP  - 45
VL  - Volume 2
IS  - İssue 1 (1)
KW  - THE PROTECTIVE ROLE OF ERDOSTEINE AGAINST CYCLOSPORINE A- INDUCED TESTICULAR TOXICITY
N2  - The use of Cyclosporine A (CsA) in cancer isincreasing based on its inhibiting effect on the calcineurin/nuclear factor ofactivated T-cells (NFAT) pathway in immune cells. However, its oxidative stressrelated toxic side effects reduces its therapeutic potential. Therefore, theprotective effect of Erdosteine (ER) against CsA-induced injury in rat testiswas firstly investigated in the present study. 32 Wistar albino male rats wererandomly divided into four groups; control, CsA (20 mg/kg/day i.p.), CsA + ER(ER 12 mg/kg/day orally) and only ER. Malondialdehyde (MDA), catalase (CAT),nitrite/nitrate (expressed as NO), superoxide dismutase (SOD) and glutathion peroxidase(GSH-Px) levels were evaluated in addition to histological analysis. MDA and NOlevels were significantly increased in CsA group compared to control group.However, MDA and NO levels significantly decreased in CsA + ER groups comparedto CsA group (p <0,05). Antioxidant enzymes CAT and GSH-Px activities in CsAgroup were significantly lower than control group, while CAT activities in CsA+ ER were significantly lower than other groups (p<0,05). Histologicaldegeneration in CsA group was significant compared to other groups. Improvementin ER + CsA group was significant compared to CsA group. In conclusion ER couldhave a protective role against testicular injury induced by CsA with itsantioxidant properties
CR  - Turgut Ozal University Vocational School of Health Sciences Pathology Laboratory Tecniques Programme, Ankara
CR  - Mustafa Kemal University, Medical Faculty, Department of Biochemistry, Antakya, Hatay
CR  - Akdeniz University, Medical Faculty, Department of Biochemistry, Antalya
UR  - https://dergipark.org.tr/tr/pub/turjoem/issue//303920
L1  - https://dergipark.org.tr/tr/download/article-file/290925
ER  -