TY  - JOUR
TT  - DYNAMIC DISULFIDE/THIOL HOMEOSTASIS IN FIREFIGHTER’S LUNG DISEASE DETECTION
AU  - Gündüzöz, Meşide
AU  - Bal, Ceylan
AU  - Çetintepe, Sultan Pınar
AU  - Büyükşekerci, Murat
AU  - Alışık, Murat
AU  - Erdoğan, Serpil
AU  - İritaş, Servet Birgin
AU  - Yılmaz, Hınç
AU  - Tutkun, Engin
AU  - Erel, Özcan
PY  - 2017
DA  - February
JF  - The Turkish Journal Of Occupational / Environmental Medicine and Safety
JO  - turjoem
PB  - Engin TUTKUN
WT  - DergiPark
SN  - 2149-4711
SP  - 48
EP  - 48
VL  - Volume 2
IS  - İssue 1 (1)
KW  - DYNAMIC DISULFIDE/THIOL HOMEOSTASIS IN FIREFIGHTER’S LUNG DISEASE DETECTION
N2  - The potentialfor firefighters to involve acute and/or chronic respiratory healthconsequences associated with exposures during firefighting activities has longbeen recognized. In the state of oxidativestress thiolsoxidized to disulfide form via reversible thiol-disulphideexchange reactions. Due to the possibly raised risk for the development of airwaysdisease among firefighters, it is important that functional respiratoryabnormalities be recognized earlier.One hundredfirefighters who admitted for periodic medical examination and fifty controlsubjects working as officers were recruited as control group. Firemen were classified into threesubgroups: Group 1 consists of those having pulmonary pathology, group 2comprises those suffering from respiratory disorder, and group 3 contains thosehaving both pulmonary pathology and respiratory disorder.50 officerswere recruited as control group. Urine arsenicand serum disulfide/thiol homeostasis were measured.Urine arsenic,serum disulphide and % disulfid/ native thiollevels of firefighterswere foundsignificantly higher than control subjects (p<0.001).  In subgroup analyses; group 1,2 and 3 weredifferent from control group in terms of arsenic, disulphide and % disulfid/native thiollevels(p<0.001). Also there is a significantdifference betweengroup 1 and group 2 and between group 1 and 3 in terms of disulphide and %disulfid/ native thiol levels (p<0.001).We revealed forthe first time that disulphide levels, a biomarker of oxidative stress, weresignificantly higher in wildfirefighters.
CR  - Department of Family Medicine, Occupational Diseases Hospital, Ankara, Turkey
CR  - Department of Biochemistry, Yıldırım Beyazıt University, Ankara, Turkey
CR  - Department of Internal Medicine, Hacettepe University, Ankara, Turkey
CR  - Department of Pharmacology, Occupational Diseases Hospital, Ankara, Turkey
CR  - Department of Biochemistry, Atatürk Educational and Research Hospital, Ankara, Turkey
CR  - The Council of Forensic Medicine of Ankara, Turkey
CR  - Department of Toxicology, Occupational Diseases Hospital, Ankara, Turkey
UR  - https://dergipark.org.tr/tr/pub/turjoem/issue//303931
L1  - https://dergipark.org.tr/tr/download/article-file/290937
ER  -