@article{article_304530, title={Effect of montelukast on hepatic and renal ischemia/reperfusion injury}, journal={Turkish Journal of Clinics and Laboratory}, volume={8}, pages={43–51}, year={2017}, DOI={10.18663/tjcl.304530}, url={https://izlik.org/JA63WC27CZ}, author={Budak, Ali Baran and Korkmaz, Kemal and Gedik, Hikmet Selçuk and Lafçı, Gökhan and Kaya, Ertuğrul and Ankaralı, Handan and Günaydın, Serdar}, keywords={İskemi-reperfüzyon injurisi,montelukast,böbrek,karaciğer}, abstract={<p class="MsoNormal" style="text-align:justify;"> <span class="hps"> <b> <span lang="en-us" style="font-size:11pt;font-family:’Myriad Pro’, sans-serif;color:#222222;" xml:lang="en-us">Aim: </span> </b> </span> <span class="hps"> <span lang="en-us" style="font-size:11pt;font-family:’Myriad Pro’, sans-serif;color:#222222;" xml:lang="en-us">The thoracoabdominal aortic
aneurysm surgery may cause splanchnic ischemia and may result in severe
postoperative complications caused by liver and/or kidney injury. This study
investigated the effect of temporary occlusion of the aorta on the development
of I/R injury of liver and kidney and the protective effect of montelukast, a
selective reverse CysLT1 receptor antagosit. </span> <span lang="en-us" xml:lang="en-us"> </span> </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;"> <span class="hps"> <span lang="en-us" xml:lang="en-us">  </span> </span> <span class="hps" style="font-size:.9em;"> <b> <span lang="en-us" style="font-size:11pt;font-family:’Myriad Pro’, sans-serif;color:#222222;" xml:lang="en-us">Material and Methods: </span> </b> </span> <span class="hps" style="font-size:.9em;"> <span lang="en-us" style="font-size:11pt;font-family:’Myriad Pro’, sans-serif;color:#222222;" xml:lang="en-us"> </span> </span> <span class="hps" style="font-size:.9em;"> <span lang="en-us" style="font-size:11pt;font-family:’Myriad Pro’, sans-serif;color:#222222;" xml:lang="en-us">Twenty-one male Sprague-Dawley
rats were randomly assigned to three groups (n=7 per group) as G1 (no aortic
occlusion and montelukast administration), G2 (45 min. aortic occlusion; no
montelukast administration) and G3 (45 min. aortic occlusion, 10 mg/kg montelukast
administration). At the 48 <sup>th </sup> hour of reperfusion, kidney and liver
samples were dissected for histopathological evaluation and immunohistochemical
staining for HSP70, interleukin-6 and myeloperoxidase (MPO). </span> </span> </p> <p class="MsoNormal" style="text-align:justify;"> <span class="hps"> <span lang="en-us" xml:lang="en-us">  </span> </span> <span class="hps" style="font-size:.9em;"> <b> <span lang="en-us" style="font-size:11pt;font-family:’Myriad Pro’, sans-serif;color:#222222;" xml:lang="en-us">Results: </span> </b> </span> <span class="hps" style="font-size:.9em;"> <span lang="en-us" style="font-size:11pt;font-family:’Myriad Pro’, sans-serif;color:#222222;" xml:lang="en-us"> Tissue
samples taken from the kidney showed significant intergroup differences in
terms of tubular cell degeneration, cytoplasmic vacuole formation, hemorrhage
and tubular dilatation (P = 0.001, P = 0.017, P = 0.001, P = 0.001
respectively). There was a significant difference with regards to HSP-70 stain
(P = 0.01) in favor of G1 and G3 with respect to G2. Hepatocyte degeneration in
the liver samples of G3 was significantly lower than that of G1 and G2 (P = 0.027). </span> </span> </p> <p class="MsoNormal" style="text-align:justify;"> <span class="hps"> <span lang="en-us" xml:lang="en-us">  </span> </span> <span class="hps" style="font-size:.9em;"> <b> <span lang="en-us" style="font-size:11pt;font-family:’Myriad Pro’, sans-serif;color:#222222;" xml:lang="en-us">Conclusion: </span> </b> </span> <span class="hps" style="font-size:.9em;"> <span lang="en-us" style="font-size:11pt;font-family:’Myriad Pro’, sans-serif;color:#222222;" xml:lang="en-us"> The
findings of the current study demonstrated that montelukast has protective
effects on both kidney and liver; and were confirmed   histopathologically and
immunohistochemically. The protective effects of montelukast can be attributed
to its potential of anti-oxidative and anti-inflammatory actions. </span> </span> </p>}, number={2}