TY - JOUR TT - PERSONALIZED MEDICINE IN SOLVING FORENSIC CASES AU - Kalfoglu, Ersi Abaci PY - 2017 DA - February JF - The Turkish Journal Of Occupational / Environmental Medicine and Safety JO - turjoem PB - Engin TUTKUN WT - DergiPark SN - 2149-4711 SP - 66 EP - 66 VL - Volume 2 IS - İssue 1 (1) KW - PERSONALIZED MEDICINE IN SOLVING FORENSIC CASES N2 - Personalizedmedicine investigates individual genetic variations in susceptibility to theforeseen effects of a drug or of xenobiotics. Indeed, adverse drug reactionscan cause morbidity or mortality and different subjects with the same diagnosiscould respond differently to the same drug administered at the same dose. Thereis a series of causes for this, one of them being genetic make-up orpolymorphisms. The human genomic sequence varies at the level of 0.1 %, meaningthat there are several millions of nucleotide differences between individuals.This genetic diversity that is expected to have no functional significance maybe the cause for death, severe disability, and heterogeneous capacity of each individualto respond to xenobiotics. The detection of these variations has beenfacilitated the last years by the enormous development that has been achievedin the field of genetics. Personalized medicine promises to optimize therapyand minimize side effects on the one hand and on the other can provide insightto issues of legal medicine like drug related deaths, unintentional poisoningand generally cases where the cause of death is unclear. As an example,substance abuse which is a public health problem worldwide has both genetic andenvironmental causes. Knowledge of genetic factors may enable theindividualization of prevention and treatment of drug addiction. Malpracticecases due to drug administration may be examined in a person-based manner for aprecise result.  Although the technologyseems highly promising, still a serious amount of research is required in orderto safely use the idea in the medico-legal context because justice is not readyto introduce this new concept easily to its system.  CR - Ersi Abaci KALFOGLU Faculty of Medicine, Yeni Yüzyıl University, Turkey UR - https://dergipark.org.tr/tr/pub/turjoem/issue//305415 L1 - https://dergipark.org.tr/tr/download/article-file/292938 ER -