TY  - JOUR
TT  - THE ROLE OF METAL METABOLISM IN OXIDATIVE STRESS
AU  - Kartal, Yasemin
AU  - Balcıoğlu, Esra
AU  - Kayaaltı, Zeliha
PY  - 2017
DA  - February
JF  - The Turkish Journal Of Occupational / Environmental Medicine and Safety
JO  - turjoem
PB  - Engin TUTKUN
WT  - DergiPark
SN  - 2149-4711
SP  - 156
EP  - 156
VL  - Volume 2
IS  - İssue 1 (1)
KW  - THE ROLE OF METAL METABOLISM IN OXIDATIVE STRESS
N2  - Metals aredivided into two groups including essential and nonessential, play important rolesin biological processes. Changes in metal ion homeostasis can lead to oxidativestress. This instance provides information that gene polymorphisms of enzymesand proteins involved in metal toxicokinetics causes possibly symptomaticeffects for numerous diseases including cancer due to playing an important rolein metal ion homeostasis. Therefore, there is an important relationship betweenmetal-induced genotoxicity and oxidative stress. Several metals like arsenic(As), cobalt (Co), chromium (Cr), lead (Pb) and copper (Cu) induce redoxreactions and the production of reactive oxygen species (ROS). For example, aswhich is one of the metals with an interest in sulfhydryl groups has aprooxidative effect. As inhibit antioxidative enzymes leads to depletion ofintracellular glutathione. In addition, as inhibits the biological activity andgreat numbers of protein metabolism such as cysteine and metallothionein. Coincreases the toxic oxygen radicals by influencing the metabolism of freeradicals and causes changes in the catabolic defense enzymes activity.  As a result of this, it disrupts the balanceof antioxidant. After entering the pulmonary absorption, the reduction of Cr(VI) to Cr(III) may reveal ROS which can lead to DNA damage and oxidativestress. As for lead, it induces damage not only production of ROS but alsodepletion of the cellular antioxidant pool. Similarly, exposure to copper athigh levels decreases glutathione levels. The aim of this review is to providean overview of metal metabolism related to oxidative stress.
CR  - Yasemin KARTAL, Esra BALCIOĞLU, Zeliha KAYAALTI
CR  - Department of Physiology, Hacettepe University, Faculty of Medicine, Turkey
 Institute of Forensic Sciences, Ankara University, Turkey
UR  - https://dergipark.org.tr/tr/pub/turjoem/issue//306114
L1  - https://dergipark.org.tr/tr/download/article-file/293866
ER  -