TY  - JOUR
TT  - THE EFFECTS OF HIGH DOSE PARACETAMOL ON THYROID FOLLICULAREPITELIAL CELLS IN RAT
AU  - Eren, Banu
AU  - Solmaz, Sare
AU  - Eren, Zafer
AU  - Mercan, Sevcan
AU  - Sağır, Dilek
AU  - Yılmaz, Burcu
PY  - 2017
DA  - February
JF  - The Turkish Journal Of Occupational / Environmental Medicine and Safety
JO  - turjoem
PB  - Engin TUTKUN
WT  - DergiPark
SN  - 2149-4711
SP  - 172
EP  - 172
VL  - Volume 2
IS  - İssue 1 (1)
KW  - THE EFFECTS OF HIGH DOSE PARACETAMOL ON THYROID FOLLICULAREPITELIAL CELLS IN RAT
N2  - ‘Analgesic’ isthe name given to any drug that is used to make an analgesic effect. Analgesicdrugs act on the central and peripheral nervous system. There are many kinds ofanalgesics such as acetaminophen, narcotic drugs, synthetic drugs with thenarcotic effect and nonsteroidal anti inflammatuary drugs (NSAID). Although theanalgesic action mechanism is unknown, in many studies paracetamol causes dosedependent significant liver and renal toxcicity, but is stil used withoutconsideration. In this study we aimed to determine the toxic effects ofparacetamol on thyroid folicular epithelial cells.For thispurpose, a total of 25 female Wistar albino rats divided into 5 groups whichare the control group (not treated) and paracetamol groups (P7, P14, P21, P28).750 mg/kg/day paracetamol was given to paracetamol groups via gavaje techniqueuntil the day they were sacrified. After light microscopic histologicalexamination cytoplasmic vacuolisation, follicular and colloidal degenerationwere detected in paracetamol groups. The average follicular diameter measurementof the tissue sample sections of the morphometric evaluation of the controlgroup (57.23±6.45) and the group P7 is examined statistically significantly(p<0.05). The average height of follicle epithelial of the control group(0.20 ± 2.19) and the differences were observed statistically significantbetween the other groups (p<0.05).Inconclusion,based on the results of histological analysis we support that 750 mg/kg/daydose of paracetamol have toxic effects on thyroid tissue depending on theduration of use.
CR  - Banu EREN, Sare SOLMAZ, Zafer EREN, Sevcan MERCAN, Dilek SAĞIR, Burcu YILMAZ
CR  - Ondokuz Mayıs Üniversitesi, Fen Edebiyat Fakültesi, Biyoloji Bölümü Genel Biyoloji Anabilim Dalı
Sinop Üniversitesi Sağlık Yüksek Okulu
Ordu Üniversitesi Meslek Yüksek Okulu
UR  - http://dergipark.org.tr/tr/pub/turjoem/issue//306140
L1  - http://dergipark.org.tr/tr/download/article-file/293898
ER  -