@article{article_307261, title={PARASPORINS AS A NATURAL ANTI-CANCER PROTEIN}, journal={Anadolu University Journal of Science and Technology C - Life Sciences and Biotechnology}, volume={6}, pages={103–113}, year={2017}, DOI={10.18036/aubtdc.307261}, author={Kesik Oktay, Müjgan and Güneş, Hatice}, keywords={Bacillus thuringiensis,parasporin,anti-kanser aktivite}, abstract={<p>Bacillus thuringiensis (Bt) is a gram positive and spore forming bacterium that shows a wide distribution in the nature.  During the sporulation phase, it produces insecticidal crystal proteins along with spores. These insecticidal proteins are called Cry and Cyt proteins and have an activity when binding to spesific receptor located on the plasma membrane of mid-gut epithelial cells of susceptible insects. This receptor mediated spesific activity makes Bt important in agricultural control of insects. Afterwards, research on non-insecticidal proteins that have a wider distribution in nature than insecticidal ones revealed a new protein class called parasporin. Parasporins are capable of discriminately killing cancer cells while does not show cytotoxic and hemolytic activity against normal cells. So far, six parasporin families have been defined and a total of 19 sub-group is known.  Because  parasporins have a similar spesific-receptor binding effect with insecticidal crystal proteins,  they had led to emergence of a new research field related to cancer treatment.  This study reviewed the discovery of parasporins, their characteristics, varieties and their mechanisms of action on cancer cells. <br /> </p>}, number={2}, publisher={Eskişehir Teknik Üniversitesi}