TY  - JOUR
TT  - HISTOPATHOLOGICAL EFFECTS OF (4S)-2-(4-HYDROXY-3-METHOXYPHENYL) THİAZOLIDINE-4-CARBOXYLIC ACID ON INTESTINE TISSUE OF ZEBRAFISH (Danio rerio)
AU  - Akbulut, Cansu
AU  - Fidan, Büşra
AU  - Zengin, Mustafa
AU  - Yön, Nazan Deniz
PY  - 2017
DA  - February
JF  - The Turkish Journal Of Occupational / Environmental Medicine and Safety
JO  - turjoem
PB  - Engin TUTKUN
WT  - DergiPark
SN  - 2149-4711
SP  - 294
EP  - 294
VL  - Volume 2
IS  - İssue 1 (1)
KW  - HISTOPATHOLOGICAL EFFECTS OF (4S)-2-(4-HYDROXY-3-METHOXYPHENYL) THİAZOLIDINE-4-CARBOXYLIC ACID ON INTESTINE TISSUE OF ZEBRAFISH (Danio rerio)
N2  - Investigationthe histopathological effects of (4s)-2-(4-hydroxy-3-methoxyphenyl)thiazolidine-4-carboxylic acid on intestine tissue of zebrafish were aimed. (4S)-2-(4-hydroxy-3-methoxyphenyl) thiazolidine-4-carboxylicacid is new synthesized substance which obtained from cysteine and valine.Because of thiazolidine derivates have important biological responses scientistwork intensively on these compounds recent years. It is obvious that thiazolidinecontained compounds will be used in future in the pharmaceutical industry totreat important diseases.After one weekadaptation period zebrafish divided into four group (n=10) as one control and 3experimental groups (0.2 mM,0.4mM 0.6mM). Intestine were dissected after 5 dayof the exposure. Tissues were fixed with 10% neutral buffered formalin anddehydration were carried out in an ascending series of ethanol. Tissues werecleared in xylene, embedded in paraffin wax and cut into 5 µm sections on a microtome.The sections were stained with hematoxylin(H&E). Results were evaluatedwith light microscope.In control groupnormal intestine histology have been observed. In 0.2 mM degeneration andfusion at villi structures and inflammation at submucosa were detected. In 0.4mM thiazolidine exposed group, degeneration and vacuolization at villistructure and hypertrophy at serosa were observed. In 0.6 mM thiazolidineexposed group, degeneration at vili structure, hypertrophy at muscularisexterna, vacuolization at submucosa and increase in the number of goblet cellswere observed.
CR  - Cansu AKBULUT, Büşra FİDAN, Mustafa ZENGİN, Nazan Deniz YÖN
CR  - Sakarya University Science and Letters Faculty Department of Biology, Sakarya, Turkey
Sakarya University Science and Letters Faculty Department of Chemistry, Sakarya, Turkey
UR  - https://dergipark.org.tr/tr/pub/turjoem/issue//315520
L1  - https://dergipark.org.tr/tr/download/article-file/306018
ER  -