TY  - JOUR
TT  - Radyoterapi Uygulanan Akciğer Kanseri Tanılı Vakalarda Radyasyon Pnömonisi Gelişimini Etkileyen Faktörler
AU  - Akçay, Melek
AU  - Özen, Alaattin
AU  - Uslu, Sema
AU  - Yıldırım, Hüseyin
AU  - Metcalfe, Evrim
AU  - Etiz, Durmuş
PY  - 2017
DA  - September
DO  - 10.20515/otd.318366
JF  - Osmangazi Tıp Dergisi
PB  - Eskişehir Osmangazi Üniversitesi
WT  - DergiPark
SN  - 1305-4953
SP  - 35
EP  - 43
VL  - 39
IS  - 3
KW  - lung cancer
KW  - 3 dimensional conformal radiotherapy (3D-CRT)
KW  - procalcitonin
N2  - Öz: Bu tek merkezliprospektif çalışmada 3 boyutlu konformal radyoterapi (3BKRT) ile tedavi edilenve normal doz-volüm histogramına (DVH) sahip akciğer kanseri tanılı hastalardaradyasyon pnömonisi (RP) gelişimini etkileyen faktörleri değerlendirmeyiamaçlandı. Çalışmaya Şubat 2012-Temmuz 2013 tarihleri arasında küratif 3BKRTuygulanan 41 akciğer kanseri tanılı hasta dahil edildi. Otuz (%73,2) hastaya eşzamanlı kemoterapi verildi. Sekiz (%19,5) hastaya adjuvant radyoterapi (RT)uygulandı. Medyan RT dozu 60 (30-64) Gy idi. Tedavi sonrası RP gelişimi ile DVHparametreleri, tedavi öncesi karbon monoksit difüzyon kapasitesi (DLCO), serumprokalsitonin, CRP ve TGF-β1 seviyeleri gibi hastaya özgü faktörler arasındakiilişki analiz edildi. Medyan 8 (6-24) aylık takip süresi içerisinde 15 (%36,6)hastada RP gelişti (11 hastada grade I, 4 hastada grade II) ve sadece 2 hastayasteroid (1 mg/kg/gün metilprednizolon) tedavisi uygulandı. Tek değişkenlianalizde lenf nodu tutulumu, DLCO ve tedavi öncesi serum prokalsitonin düzeyininRP gelişimi üzerine etkisi gösterildi (sırasıyla, p=0.018, 0,045, 0.001). Çokdeğişkenli analizde sadece tedavi öncesi serum prokalsitonin düzeyi ileistatistiksel anlamlı ilişki mevcut idi (p=0.027). Sonuç olarak tedavi öncesiserum prokalsitonin düzeyi 3BKRT ile tedavi edilen ve normal DVH değerlerinesahip akciğer kanseri tanılı hastalarda RP gelişimini tahmin etmede faydalıolabilir.
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UR  - https://doi.org/10.20515/otd.318366
L1  - https://dergipark.org.tr/tr/download/article-file/356676
ER  -