TY - JOUR TT - Deneysel hayvan çalışmalarında montelukast AU - Özpolat, Berkant PY - 2017 DA - June DO - 10.18663/tjcl.320026 JF - Turkish Journal of Clinics and Laboratory JO - TJCL PB - DNT Ortadoğu Yayıncılık A.Ş. WT - DergiPark SN - 2149-8296 SP - 1 EP - 1 VL - 8 IS - 2 KW - montelukast KW - animal study KW - experimental KW - ischemia KW - reperfusion N2 - Sonyıllarda sisteinil lökotrien (CysLT1) reseptör antagonisti, allerji ve astımtedavisinde kullanılan bir ilaç olan montelukastın deneysel çalışmalardasıklıkla kullanıldığını görmekteyiz. Bu ve benzeri birçok çalışma ışığında, ileridemontelukastın farklı alanlarda kullanılacağını öngörmek zor değil. Bunlarınbaşında inflamatuar hastalıklarda kullanımı, graft versus host reaksiyonlarınıntedavisi ve özellikle kanser tedavisi konusunda yapılacak çalışmalar başıçekecektir. CR - 1. Budak AB, Korkmaz K, Gedik HS, et al. Effect of montelucast on hepatic and renal ischemia/reperfusion injury. Turk Clin Lab 2017; 8: 43-51. CR - 2. Jung HW, Jung JK, Park YK. Comparison of the efficacy of KOB03, ketotifen, and montelukast in an experimental mouse model of allergic rhinitis. Int Immunopharmacol 2013; 16: 254-60. CR - 3. Ikeda G, Miyahara N, Koga H, et al. Effect of a cysteinyl leukotriene receptor antagonist on experimental emphysema and asthma combined with emphysema. Am J Respir Cell Mol Biol 2014; 50: 18-29. CR - 4. Sekioka T, Kadode M, Yonetomi Y, et al. CysLT2 receptor activation is involved in LTC4-induced lung air-trapping in guinea pigs. Eur J Pharmacol 2017; 794: 147-153. CR - 5. Tu ZL, Zhou ZY, Xu HC,et al. LTB4 and montelukast in transplantation-related bronchiolitis obliterans in rats. J Cardiothorac Surg 2017; 12: 43. CR - 6. Kim BH, Park M, Park HJ, et al. Prolonged, acute suppression of cysteinyl leukotriene to reduce capsular contracture around silicone implants. Acta Biomater 2017; 51: 209-219. CR - 7. Yang JD, Kwon OH, Lee JW, et al. The effect of montelukast and antiadhesion barrier solution on the capsule formation after insertion of silicone implants in a white rat model. Eur Surg Res 2013; 51: 146-55. CR - 8. Polat A, Canbora MK, Akakin D, Aykanat F. Effects of montelukast sodium on tendon healing: An experimental study. Indian J Orthop 2013; 47: 500-4. CR - 9. Marschallinger J, Schäffner I, Klein B, et al. Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug. Nat Commun 2015; 6: 8466. CR - 10. Kumar A, Prakash A, Pahwa D, Mishra J. Montelukast potentiates the protective effect of rofecoxib against kainic acid-induced cognitive dysfunction in rats. Pharmacol Biochem Behav 2012; 103: 43-52. CR - 11. Kuru S, Kismet K, Barlas AM, et al. The Effect of Montelukast on Liver Damage in an Experimental Obstructive Jaundice Model. Viszeralmedizin 2015; 31: 131-8. CR - 12. Angı S, Eken H, Kılıc E, Karaköse O, Balci G, Somuncu E. Effects of Montelukast in an Experimental Model of Acute Pancreatitis. Med Sci Monit 2016; 22: 2714-9. CR - 13. Eskicioğlu F, Turan GA, Sivrikoz ON, et al. Montelukast is effective in preventing of ovarian hyperstimulation syndrome; an experimental study. Ginekol Pol 2015; 86: 566-73. CR - 14. Cavus G, Altas M, Aras M, et al. Effects of montelukast and methylprednisolone on experimental spinal cord injury in rats. Eur Rev Med Pharmacol Sci 2014; 18: 1770-7. CR - 15. Genovese T, Rossi A, Mazzon E, et al. Effects of zileuton and montelukast in mouse experimental spinal cord injury. Br J Pharmacol 2008; 153: 568-82. CR - 16. Uçar S, Huseynov T, Çoban M, Sarıoğlu S, Serbetçioğlu B, Yalcin AD. Montelukast is as effective as penicillin in treatment of acute otitis media: an experimental rat study. Med Sci Monit Basic Res 2013; 19: 246-52. CR - 17. Savari S, Liu M, Zhang Y, Sime W, Sjölander A. CysLT(1) R antagonists inhibit tumor growth in a xenograft model of colon cancer. PLoS One 2013; 8: e73466. UR - https://doi.org/10.18663/tjcl.320026 L1 - https://dergipark.org.tr/tr/download/article-file/312414 ER -