TY - JOUR TT - Role of cytokine gene polymorphisms on ramipril-altered inflammatory response and myocardial injury in patients undergoing coronary artery bypass surgery AU - Küçük, Meral Urhan AU - Karaca, Kerem AU - Fırat, Seyhan Şahan AU - Vezir, Özden , AU - Canacankatan, Necmiye AU - Aytaçoğlu, Barlas Naim AU - Erden, Sema AU - Tunçtan, Bahar AU - Sucu, Nehir PY - 2017 DA - September Y2 - 2016 DO - 10.17826/cutf.323386 JF - Cukurova Medical Journal JO - Cukurova Med J PB - Çukurova Üniversitesi WT - DergiPark SN - 2602-3032 SP - 436 EP - 445 VL - 42 IS - 3 KW - ACE inhibitörleri KW - sitokin KW - polimorfizm N2 - Purpose: Ramipril is effective in treating inflammatory myocardial injury by reducing cytokines such as TNF-α, IL-6, and IL-8. In this study, we investigated the effect of cytokine gene polymorphisms on inflammatory response which might be reduced by ramipril.Material and Methods: Of 102 patients undergoing on-pump coronary artery bypass grafting surgery, 51 were the treatment group which received ramipril and the remaining 51 were the non-treated control group. TNF-α, IL-6, and IL-8 were measured with Enzyme-Linked Immuno Sorbent Assay (ELISA), before anesthesia induction (t1), at 20 min following cross clamping (t2), at the end of the operation (t3), and 24 hours after anesthesia (t4). Genotyping was performed with PCR method.Results: While TNF-α increase began with surgery, IL-6 and IL-8 increase began with cardiac arrest during cardiopulmonary bypass and continued until the end of the operation. In contrast, only IL-8 remained high in the control group during the postoperative period, while TNF-α, IL-6, and IL-8 began to decrease. 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