@article{article_336837, title={Plasma Urotensin II Concentration In Gestational Diabetes}, journal={Archives of Clinical and Experimental Medicine}, volume={2}, pages={66–70}, year={2017}, DOI={10.25000/acem.336837}, author={Hursitoglu, Mehmet and Ekiz, Ali and Mete, Fatih and Okuturlar, Yıldız and Kocoglu, Hakan and Dumanli, Guleren and Cakirca, Mustafa and Anataca, Gulden and Kuru, Oguzhan and Dogan, Serkan and et al.}, keywords={ürotensin,gestasyonel diabet,gebelik,glukoz tolerans testi}, abstract={<p class="MsoNormal" style="margin-bottom:.0001pt;line-height:200%;"> <span lang="en-gb" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-gb"> <span style="font-size:14px;">Aim: Urotensin II
(UII) and its system is implicated in the etiology of many diseases (including diabetes
mellitus). We tried in this study to evaluate and compare UII levels in
gestational diabetes mellitus (GDM). </span> </span> </p> <p> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;line-height:200%;"> <span lang="en-gb" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-gb"> <span style="font-size:14px;">Methods: Thirty-six
pregnant women (15 non-GDM patients consisted group 1 and 21 GDM patients
consisted group 2) enrolled in this study. The 3rd group consisted of age matched
22 non pregnant healthy women. Plasma UII levels were determined at the
beginning of the study. After 12 weeks of delivery, a second plasma UII was determined
from group 1 and 2. </span> </span> </p> <p> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;line-height:200%;"> <span lang="en-gb" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-gb"> <span style="font-size:14px;">Results: Gestational
UII levels of both GDM and non-GDM patients were higher than non-pregnant
healthy controls (p=0.0001 for both). Both gestational and postpartum UII
levels of GDM patients were higher than non-GDM patients but had not reached statistical
significance (P≥0.05). Plasma UII concentrations in non-GDM patients significantly
decreased after delivery but not in GDM patients (p=0.036 and p≥0.05,
respectively). </span> </span> </p> <p> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;text-align:justify;line-height:200%;"> <span style="font-size:14px;"> </span> <span style="font-size:14px;"> </span> <span style="font-size:14px;"> </span> </p> <p class="MsoNormal" style="margin-bottom:.0001pt;line-height:200%;"> <span lang="en-gb" style="font-size:12pt;line-height:200%;font-family:’Times New Roman’, serif;" xml:lang="en-gb"> <span style="font-size:14px;">Conclusion: The
finding of elevated gestational plasma UII concentrations in GDM patients which
did not decrease significantly after delivery (in compare to non-GDM patients) shows
that plasma UII levels may have a role in the pathogenesis of GDM. Further
detailed studies are needed in this field. </span> </span> </p> <p> </p> <p> <b> </b> </p> <b> </b>}, number={3}, publisher={Mustafa HASBAHÇECİ}