TY - JOUR T1 - İKİ OLGU İLE HEREDİTER ANJİYOÖDEMLİ HASTALARA PREOPERATİF YAKLAŞIMIN GÖZDEN GEÇİRİLMESİ TT - Preoperative Approach to Hereditary Angioedema Patients in Two Cases AU - Nazik, Hülya AU - Öztürk, Perihan AU - Mülayim, Mehmet Kamil AU - Dalyan, İnci PY - 2018 DA - August DO - 10.24938/kutfd.341226 JF - The Journal of Kırıkkale University Faculty of Medicine JO - Kırıkkale Uni Med J PB - Kırıkkale Üniversitesi WT - DergiPark SN - 2148-9645 SP - 221 EP - 225 VL - 20 IS - 2 LA - tr AB - Küçük veyabüyük cerrahi işlem planlanan herediter anjiyoödem olguları için preoperatifdönemde proflaktik tedavinin önemi, perioperatif ve postoperatif dönemdekarşılaşılabilecek sorunlar konusuna dikkat çekilmesi amaçlanmıştır. Herediteranjiyoödem tanısı ile takibi süren 2 olguya minör cerrahi işlemden 1-6 saatönce 1000 IU C1 esteraz inhibitörü uygulandı. Olgu 1'de işlem sırasında vesonraki bir ayda atak gelişmedi. İnkomplet lupus eritematozusu olan olgu 2’deise işlemden bir saat sonra dudakta anjiyoödem ortaya çıktı. Hastaya bir dozdaha C1 esteraz inhibitörü verildi ve anjiyoödem yarım saat içinde geriledi. Buçalışmada herediter anjiyoödemli hastalarda işlem sırasında atak gelişimineengel olmak için proflaktik tedavinin önemine dikkat çekilmesi amaçlanmıştır. KW - proflaksi KW - Herediter anjiyoödem KW - C1 esteraz inhibitörü N2 - Our aim isto draw attention to the importance of prophylactic treatment in preoperative,perioperative and postoperative period for hereditary angioedema patients forwhom minor or major surgery is planned. Two patients with a diagnosis ofhereditary angioedema were treated with 1000 IU C1 esterase inhibitor 1-6 hoursbefore minor surgery. Case 1 did not develop an attack during the procedure andwithin postoperative one month. In case 2 with incomplete lupus erythematosus,angioedema occurred in the lips one hour after the procedure. One more dose ofC1 esterase inhibitor was administered to the patient and angioedema wasdelayed within half an hour. In this study, it was aimed to emphasize theimportance of prophylactic treatment to prevent attack development during theprocedure in patients with hereditary angioedema. CR - 1. Bhardwaj N, Craig TJ. Treatment of hereditary angioedema: A review (CME). Transfusion. 2014;54(11):2989-96. CR - 2. Cicardi M, Aberer W, Banerji A, Bas M, Bernstein JA, Bork K, et al. Classification, diagnosis, and approach to treatment for angioedema: Consensus report from the Hereditary Angioedema International Working Group. Allergy. 2014;69(5):602-16. CR - 3. Craig T, Shapiro R, Vegh A, Baker JW, Bernstein JA, Busse P, et al. Efficacy and safety of an intravenous C1-inhibitor concentrate for long-term prophylaxis in hereditary angioedema. Allergy Rhinol (Providence). 2017;8(1):13-9. CR - 4. Gurmen ES, Dogan S, Sert E, Dikmetas C, Hussein S. Effect of C1 esterase inhibitor in hereditary angioedema treatment. Am J Emerg Med. 2017;35(6):942. CR - 5. Teranishi R, Makino Y, Amano E, Shibuya H, Okada T. Perioperative management of a patient with hereditary angioedema: a case report. Masui. 2015;64(4):441-3. CR - 6. Steiner UC, Weber-Chrysochoou C, Helbling A, Scherer K, Grendelmeier PS, Wuillemin WA. Hereditary angioedema due to C1-inhibitor deficiency in Switzerland: clinical characteristics and therapeutic modalities within a cohort study. Orphanet J Rare Dis. 2016;11:43. CR - 7. Sarici G, Koca R, Tekin NS, Altinyazar HC. A family with hereditary angioedema having been followed as familial mediterranean fever. Archives of the Turkish Dermatology and Venerology. 2009;43:29-31. CR - 8. Henao MP, Kraschnewski JL, Kelbel T, Craig TJ. Diagnosis and screening of patients with hereditary angioedema in primary care. Ther Clin Risk Manag. 2016;12:701-11. CR - 9. Kus S, Yucelten D. Hereditary Angioedema: Report of Three Cases and Approach to Diagnosis and Management. Turkish Journal of Dermatology. 2009;3:43-6. CR - 10. Ekinci Z, Ozturk K. Systemic lupus erythematosus with C1q deficiency: treatment with fresh frozen plasma. Lupus. 2018;27(1):134-8. CR - 11. Maynard AA, Burger CF, Schlesinger JJ. Angioedema: Perioperative management. Open Med Case Rep. 2017;5:1-4. CR - 12. Greve J, Strassen U, Gorczyza M, Dominas N, Frahm UM, Mühlberg H et al. Prophylaxis in hereditary angioedema (HAE) with C1 inhibitor deficiency. J Dtsch Dermatol Ges. 2016;14:266-75. CR - 13. Pathria M, Krishnaswamy G, Guarderas JC. Hereditary angioedema: Implications of management. South Med J. 2017;110(2):101-6. CR - 14. Williams A, Craig T. Perioperative management of patients with hereditary angioedema. Allergy Rhinol. 2015;6:50-5. UR - https://doi.org/10.24938/kutfd.341226 L1 - https://dergipark.org.tr/tr/download/article-file/515495 ER -