TY  - JOUR
T1  - THE WORTHINESS OF OVARY SYMPTOM INDEX, CA125 AND TRANSVAGINAL ULTRASONOGRAPHY IN SCREENING MALIGNANCIES OF ADNEXIAL MASSES
TT  - ADNEKSİYAL KİTLELERİN MALİGNİTE TANISINDA  OVER KANSERİ SEMPTOM İNDEKSİ, CA 125 VE TRANSVAJİNAL ULTRASONOGRAFİNİN DEĞERLİLİĞİ
AU  - Takmaz, Özge Kaymaz
AU  - Anğın, Ali Doğukan
AU  - Pirimoğlu, Zehra Meltem
PY  - 2018
DA  - March
DO  - 10.16948/zktipb.346023
JF  - Zeynep Kamil Tıp Bülteni
PB  - Zeynep Kamil Kadın ve Çocuk Hastalıkları EAH
WT  - DergiPark
SN  - 1300-7971
SP  - 54
EP  - 58
VL  - 49
IS  - 1
LA  - en
AB  - Objective:To evaluate the efficiency of Ovarian Cancer Symptom Index questionnaire byitself to define malignancy in patients with adnexial mass and to evaluateadditional effect of CA125 andtransvaginal ultrasonography on the index. Materialsand Methods: 79 patients being prepared for operation because of adnexialmass in our clinic has been included inour study. Ovarian Cancer Symptom Index, CA125, transvaginal ultrasonographyparameters were determined in preoperative term. Types, frequencies, severityand duration of symptoms were questionned and compared benign and malign cases.Parameters were compared with histopathology results after the surgery. Results: We did not find difference ofOvarin Cancer Syptom Index positivity between women with benign and malignadnexial mass (p>0.05). The sensitivity, specifity, positive predictivevalue, negative predictive value of Ovarin Cancer Syptom Index by itself were%68, %65, 0.41, 0.61 consequently. When we used The Symptom Index combined with CA125, wecalculated sensitivity %73, spesifity %64, pozitive predictive value 0.32 andnegative predictive value 0,76. The symptoms of abdominal pain, bloating,distension, eating disorders were significantly different between the groups. Wefound that Ultrasonographic Morphologic Scoring System by Sassone et al. wassignificant to differentiate malign and benign masses preoperatively. Conclusion:Contemporary Ovarian Cancer Symptom Index used in this study has notenough efficiency itself to differentiate malign and benign adnexial masses.Itwould be more useful to arrange a new symptom index for the diagnosis ofovarian cancer by using the symptoms which were significant to determinemalignancy in our study.
KW  - ovarian cancer
KW  - sypmtom
KW  - index
KW  - CA-125 antigen
N2  - Amaç:Over Kanseri Semptom İndeksi’nin, tek başına malign adneksiyal kitlelerintanınmasındaki etkinliğinin; CA125 ve transvajinalultrasonografi indeksinin tanı etkinliğine katkısının değerlendirilmesi. Gereç ve Yöntem: Çalışmamıza kliniğimizdeadneksiyal kitle nedeniyle operasyona hazırlanan 79 hasta dahil edildi.Preoperatif dönemde CA125, transvajinal ultrasonografi ve Over Kanseri Semptomİndeksi parametreleri değerlendirildi. Semptom tipleri, sıklığı, şiddeti vesüresi sorgulanarak malign ve benign vakalar karşılaştırıldı. Operasyonsonrasında kullanılan parametreler histopatolojik tanılarıyla karşılaştırıldı. Bulgular: Over kanseri Semptom İndeksipozitifliğini karşılaştırdığımızda malign ve benign adneksiyal kitlesi olankadınlarda anlamlı fark bulunmadı (p>0.05). Over Kanseri Semptom İndeksinintek başına sensitivitesi%68, spesifitesi %65, pozitif prediktifdeğer 0.41, negatif prediktif değer 0.61 olarak saptandı. Çalışmamızda semptom indekspozitifliğinin evre değerlendirilmesinde de anlamlı olmadığını gözlemledik. Semptom indeks ve CA125 birlikte kullanıldığında ise sensitivite %73,spesifite %64, pozitif prediktif değer 0.32, negatif prediktif değer 0.76olarak hesaplandı. Semptom İndeksi sorgulamasında abdominal ağrı, abdominalşişkinlik, distansiyon, yeme bozuklukları semptomları kendi başlarına gruplararasında anlamlı farklılıklar gösterdi. Sonuç:Varolan Over Kanseri Semptom İndeksi, malign ve benign ayrımında tek başınakullanılacak etkinliğe sahip değildir. Malignite tanısında anlamlı farkgösteren indeksteki spesifik semptomların değerlendirmeye alınarak daha etkinbir semptom indeksi oluşturulması over kanserli kadınların tanısında dahayararlı olacaktır.
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UR  - https://doi.org/10.16948/zktipb.346023
L1  - https://dergipark.org.tr/tr/download/article-file/445583
ER  -