@article{article_358521, title={Does Nitrous Oxide Affect the Corneal Endothelium? A Prospective Randomized Study in Pediatric Patients}, journal={Anatolian Clinic the Journal of Medical Sciences}, volume={23}, pages={20–25}, year={2018}, DOI={10.21673/anadoluklin.358521}, author={Özkan, Ahmet Selim and Akbaş, Sedat and Polat, Nihat and Yalın, Mehmet Rıdvan}, keywords={azot oksit,kornea endoteli,çocuk,genel anestezi}, abstract={<p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Aim: </span> </b> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">To evaluate
the mean changes for endothelial cell and corneal pachymetry in eyes which
underwent general anesthesia with N <sub>2 </sub>O and O <sub>2 </sub> with
sevoflurane. </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Material and
methods: </span> </b> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">40 eyes of <b> </b>40
patients who had extraocular surgery under general anesthesia included in this
prospective study. The cases divided to two groups as O <sub>2 </sub> and N <sub>2 </sub>O.
%50 O <sub>2 </sub>(total flow rate; 2 L/min in O <sub>2 </sub>-air mixture) and %50
O <sub>2 </sub>(total flow rate; 2 L/min in O <sub>2 </sub>-N <sub>2 </sub>O
mixture) were used in each group respectively. The duration of surgery was
recorded. CD (Cell Density), CV (Cell Variation), Hex (Hexagonality Rate) and
pachymetric specular microscopy results were evaluated before surgery, 1. week
and 4. week after surgery. </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Results: </span> </b> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;border:1pt none;padding:0cm;" xml:lang="en-us">The
duration of surgery and demographic data of groups were similar and
statistically there was no significant difference between the groups. The value
of CV for </span> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">O <sub>2 </sub>group was <span style="border:1pt none;padding:0cm;">26
± 2 </span> cell/mm <sup>2 </sup> <span style="border:1pt none;padding:0cm;"> </span>and <span style="border:1pt none;padding:0cm;">for </span>N <sub>2 </sub>O <span style="border:1pt none;padding:0cm;"> group was 30 </span>cell/mm <sup>2 </sup> <span style="border:1pt none;padding:0cm;">at the 1. week </span>. <span style="border:1pt none;padding:0cm;">Statistically </span>there was <span style="border:1pt none;padding:0cm;">significant
increase in </span>N <sub>2 </sub>O group compared with preoperative values <span style="border:1pt none;padding:0cm;"> (p=0,008). The value of Hex for </span>O <sub>2 </sub>group was <span style="border:1pt none;padding:0cm;">52 ± 10% </span>and <span style="border:1pt none;padding:0cm;">for </span>N <sub>2 </sub>O <span style="border:1pt none;padding:0cm;"> was 62 ± 11% at the 1.week and statistically </span>there was <span style="border:1pt none;padding:0cm;"> significant increase in </span>N <sub>2 </sub>O group compared with
preoperative values <span style="border:1pt none;padding:0cm;"> (p=0,007). </span>There <span style="border:1pt none;padding:0cm;"> was no significant difference between groups i </span>n terms of
CD, CV, Hex, pachymetry at other times. </span> </p> <p> </p> <p class="MsoNormal" style="text-align:justify;line-height:150%;"> <b> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">Conclusion: </span> </b> <span lang="en-us" style="font-size:12pt;line-height:150%;font-family:’Times New Roman’, serif;" xml:lang="en-us">There is
only significant change at the 1.week after surgery in corneal variation and
hexagonality rate in pediatric cases who had general anesthesia with nitrous
oxide and further work is needed in this regard. </span> </p> <p> </p>}, number={1}, publisher={Hayat Sağlık ve Sosyal Hizmetler Vakfı}