TY  - JOUR
TT  - N-acetyl cysteine: Is it an option for treatment of drug induced acute pancreatitis?
AU  - Emiroğlu, Halil Haldun
AU  - Zülfikar, Osman Bülent
PY  - 2017
DA  - December
Y2  - 2017
DO  - 10.16899/gopctd.358803
JF  - Çağdaş Tıp Dergisi
JO  - J Contemp Med
PB  - Rabia YILMAZ
WT  - DergiPark
SN  - 2146-6009
SP  - 385
EP  - 390
VL  - 7
IS  - 4
KW  - Pankreatit
KW  - N-asetil sistein
N2  - AbstractAim: Drugs are arelatively rare cause of acute pancreatitis. We aimed a retrospectiveevaluation of 6 patients with drug induced acute pancreatitis, who wererecovered after N-acetyl cysteine treatment.Materialsand Methods: . The information in thefiles of 6 patients with drug induced acute pancreatitis who were improvedafter NAC treatment between 2007 and2017 was retrospectively reviewed. The criteria recommended by theInternational Study Group of Pediatric Pancreatitis were used for the diagnosisof acute pancreatitis in 6 patients. The severity of the disease was determinedaccording to NASPGHAN criteriaResults: All of the 6patients with drug induced acute pancreatitis who underwent NAC during thetreatment of acute pancreatitis were completely healed.Conclusion: NAC treatmentseems to be beneficial for drug induced acute pancreatitis.
CR  - 1.	Johnson K, McEvoy CE, Naqvi S, et al. High-dose oral N-acetylcysteine fails to improve respiratory health status in patients with chronic obstructive pulmonary disease and chronic bronchitis: a randomized, placebo-controlled trial. Int J Chron Obstruct Pulmon Dis 2016;11:799-807.
2.	Smilkstein MJ, Bronstein AC, Linden C, Augenstein WL, Kulig KW, Rumack BH. Acetaminophen overdose: a 48-hour intravenous N-acetylcysteine treatment protocol. Ann Emerg Med 1991;20(10):1058–63.
3.	Bucaretchi F, Fernandes CB, Branco MM, et al. Acute liver failure in a term neonate after repeated paracetamol administration. Rev Paul Pediatr 2014;32(1):144-8.
4.	Dart RC, Erdman AR, Olson KR, et al. Acetaminophen poisoning: An evidence-based consensus guideline for out-of-hospital management. Clin Toxicol (Phila) 2006;44(1):1–18.
5.	Mumtaz K, Azam Z, Hamid S, et al. Role of N-acetylcysteine in adults with non-acetaminophen-induced acute liver failure in a center without the facility of liver transplantation. Hepatol Int 2009; 3(4): 563-70.
6.	Hu J, Zhang Q, Ren X, Sun Z, Quan Q. Efficacy and safety of acetylcysteine in "non-acetaminophen" acute liver failure: A meta-analysis of prospective clinical trials. Clin Res Hepatol Gastroenterol 2015; 39(5):594-9.
7.	Saleem AF, Abbas Q, Haque AU. Use of N-acetylcysteine in children with fulminant hepatic failure caused by acuteviral hepatitis. J Coll Physicians Surg Pak. 2015; 25(5):354-8.
8.	Schlang HA. Acetylcysteine in the removal of a bezoar. JAMA 1970;214(7):1329.
9.	Rescola FJ, Grosfeld JL, West KJ, Vane DW. Changing patterns of treatment and survival in neonates with meconium ileus. Arch Surg 1989;124(7):837–40.
10.	Lowe ME. Pancreatitis. In: Wyllie R, Hyams JS, Kay M, eds. 5th ed. Pediatric Gastrointestinal and Liver Disease. Philadelphia: Elsevier; 2016. p.1016-26.
11.	Sevillano S, De la Mano AM, De Dios I, Ramudo L, Manso MA. Major pathological mechanisms of acute pancreatitis are prevented by N-acetylcysteine. Digestion 2003;68(1):34-40.
12.	Sevillano S, De Dios I, De la Mano AM, Manso MA. N-acetylcysteine induces beneficial changes in the acinar cell cycle progression in the course of acute pancreatitis. Cell Prolif 2003;36(5):279-89.
13.	Sateesh J, Bhardwaj P, Singh N, Saraya A. Effect of antioxidant therapy on hospital stay and complications in patients with early acute pancreatitis: a randomised controlled trial. Trop Gastroenterol 2009;30(4):201-6.
14.	Morinville VD, Husain SZ, Bai H, et al. Definitions of pediatric pancreatitis and survey of current clinical practices: report from Insppire (International Study Group Of Pediatric Pancreatitis: In Search For A Cure). J Pediatr Gastroenterol Nutr 2012; 55(3): 261-5.
15.	Abu-El-Haija M, Kumar S, Szabo F, Werlin S, Conwell D, Banks P, et al. Classification of acute pancreatits in the pediatric population: Clinical report from the NASPGHAN pancreas committee. J Pediatr Gastroenterol Nutr 2017;64(6): 984–990
16.	Badalov N, Baradarian R, Kadirawel I, et al. Drug-induced acute pancreatitis: an evidence-based review. Clin Gastroenterol Hepatol 2007; 5(6): 648-61.
17.	Wu SF, Chen AC, Peng CT, Wu KH. Octreotide therapy in asparaginase-associated pancreatitis in childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 2008; 51(6): 824-5.
18.	Suzuki M, Takata O, Sakaguchi S, Fujimura J, Saito M, Shimizu T. Retherapy using L-asparaginase with octreotide in a patient recovering from L-asparaginase-induced pancreatitis. Exp Hematol 2008; 36(3): 253-4.
19.	Suzuki M, Sai JK, Shimizu T. Acute pancreatitis in children and adolescents. World J Gastrointest Pathophysiol 2014; 5(4): 416-26
20.	Wang R, Yang F, Wu H, et al. High-dose versus low-dose octreotide in the treatment of acute pancreatitis: a randomized controlled trial. Peptides 2013; 40: 57-64.
21.	Mumcu S, Alhan E, Türkyilmaz S, Kural BV, Erçin C, Kalyoncu NI. Effects of N-acetylcysteine on acute necrotizing pancreatitis in rats. Eur Surg Res 2005; 37(3): 173-8.
22.	Eşrefoğlu M, Gül M, Ates B, Batçioğlu K, Selimoğlu MA. Antioxidative effect of melatonin, ascorbic acid and N-acetylcysteine on caerulein-induced pancreatitis and associated liver injury in rats. World J Gastroenterol 2006;12(2): 259-64.
UR  - https://doi.org/10.16899/gopctd.358803
L1  - https://dergipark.org.tr/tr/download/article-file/381628
ER  -