TY - JOUR T1 - Plasma visfatin concentrations in hypothyroid patients and its relationship with thyroid autoimmunity and atherosclerosis TT - Hipotiroid hastalarda plazma visfatin konsantrasyonlarının tiroid otoimmünitesi ve ateroskleroz ile ilişkisi AU - Ucan, Bekir AU - Kebapci, M. Nur AU - Uslu, Sema AU - Kara, Mehmet AU - Akcar Degirmenci, Nevbahar AU - Oner, Setenay PY - 2018 DA - December DO - 10.21601/ortadogutipdergisi.364345 JF - Ortadoğu Tıp Dergisi JO - omj PB - MEDİTAGEM Ltd. Şti. WT - DergiPark SN - 2548-0251 SP - 498 EP - 505 VL - 10 IS - 4 LA - en AB - Aim:Visfatin/pre-B cell enhancement factorstimulates theproduction of inflammatory cytokines released from adipose tissue such as TNF-αand IL-6, which are shown to be related to the pathogenesis of insulinresistance, diabetes, dyslipidemia, inflammation, autoimmune diseases, andatherosclerosis. Our aim was to evaluate plasma visfatin concentrations inpatients with autoimmune hypothyroidism and its relationship with thyroidautoimmunity and atherosclerosis.Material and Method:Thirty-five patients with newly diagnosed Hashimoto’s thyroiditis(32 women/3 men, mean age 43.8±9.6 years) and 18 healthy controls (17 women/1men, mean age 43.3±5.2 years) were enrolled in the study. Anthropometricmeasurements, carotid intima-media thickness (CIMT), serum anti-Tg, anti-TPO,hsCRP, homocysteine, lipo(a), ApoA, ApoB1, β-2 microglobulin, insulin, glucose,visfatin, IL6, TNF-α, oxidized-LDL concentrations, lymphocyte subgroups andlipid profile were investigated both before and after thyroid hormonereplacement therapy. Serum visfatin concentrations were determined byenzyme-linked immunosorbent assay (ELISA).Results: Mean serum visfatin concentrations were similar between autoimmunehypothyroidism group and control group (6.29 ± 1.63 ng/ml to 6.36 ± 1.51 ng/ml,p>0.05) and it was not correlated with thyroid autoimmunity andatherosclerosis markers. Plasmavisfatin, oxidized LDL, IL-6, and TNF-α concentrations did not differstatistically between the control group and hypothyroid patients both beforeand after the therapy. The cardiovascular risk factors for systolic anddiastolic blood pressure, HOMA-IR index, triglyceride, Apo B and ApoB/ApoA,homocysteine, β-2 microglobulin, and CIMT were found to be elevated inpatients. Ox-LDL, cholesterol, homocysteine, and proteinuria concentrationswere positively correlated with anti-Tg concentrations.Conclusion:Serum visfatin concentrations were not associated with thyroidautoimmunity and atherosclerosis. KW - Visfatin KW - autoimmune hypothyroidism KW - atherosclerosis N2 - Amaç:Visfatin/pre-B cell enhancement factor; insülin direnci, diyabet,dislipidemi, inflamasyon, otoimmun hastalıklarve aterosklerozpatogeneziyle ilişkili adipoz dokudan salınan TNF-alfa ve IL-6 gibi inflamatuarsitokinlerin yapımını uyarır. Bu çalışmada amacımız otoimmün hipotiroidizmlihastalarda plazma visfatin düzeyi ve bunun tiroid otoimmünitesi ve aterosklerozileilişkisini değerlendirmektir.Gereç ve Yöntem:Çalışmamıza 35 yeni tanı almış Hashimoto hipotiroidili olgu (32 kadın/3 erkek,ort. yaş 43.8±9.6) ve 18 sağlıklı kontrol (17 kadın/1 erkek, ort. yaş 43.3±5.2)dahil edildi. Tiroid hormon replasmanı öncesi ve sonrası antropometrikölçümler, karotid intima-media kalınlığı (KİMK), serum anti-Tg, anti-TPO,hsCRP, homosistein, lipo(a), ApoA, ApoB1, β-2 mikroglobulin, insulin, glukoz,visfatin, IL6, TNF-α, okside-LDL, lenfosit subgrupları ve lipid profileölçümleri yapıldı. Serum visfatin konsantrasyonları ELİSA yöntemiyle çalışıldı.Bulgular:Serum visfatin konsantrasyonları otoimmün hipotiroidizm grubu ilekontrol grubu arasında benzerdi (6.29 ± 1.63 ng/ml to 6.36 ± 1.51 ng/ml,p>0.05), tiroid otoimmünitesi ve ateroskleroz belirteçleriyle korelasyonusaptanmadı. Tedavi öncesi ve sonrası hipotiroidi hastalarının plazma visfatin,okside LDL, IL-6 ve TNF-α konsantrasyonları ile sağlıklı kontrol grubuarasındaistatiksel farklılık görülmedi. Sistolik ve diyastolik kanbasıncı, HOMA-IR, trigliserid, Apo B and ApoB/ApoA, homosistein, β-2mikroglobulin, KİMK gibi kardiyovasküler risk faktörleri hasta grubunda yüksekolarak bulundu. Okside-LDL, kolesterol, homosistein ve proteinuriakonsantrasyonları anti-Tg ile pozitif korele idi.Sonuç:Serum visfatin konsantrasyonları ile tiroid otoimmünitesi veateroskleroz arasında ilişki bulunmadı. CR - 1. Pearce EN, Farwell AP, Braverman LE (2003) Thyroiditis. The New England Journal of Medicine 348: 2646–2655. CR - 2. 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(2007) Visfatin, an adipocytokine with proinflammatory and immunomodulating properties. The Journal of Immunology 178: 1748–1758. UR - https://doi.org/10.21601/ortadogutipdergisi.364345 L1 - https://dergipark.org.tr/tr/download/article-file/584420 ER -