TY - JOUR T1 - Epidemik Dönemde Şanlıurfa İli Pandemik H1N1 İnfluenza Olgularının Klinik Değerlendirmesi TT - Clinical Evaluation of Cases of Pandemic H1N1 Influenza in Sanliurfa Province in Epidemic Period AU - Kazanasmaz, Halil AU - Geter, Süleyman AU - Solmaz, Abdullah AU - Genç, Şakir AU - Gümüş, Hüseyin PY - 2018 DA - March Y2 - 2018 DO - 10.30565/medalanya.368195 JF - Acta Medica Alanya JO - Acta Med. Alanya PB - Alanya Alaaddin Keykubat Üniversitesi WT - DergiPark SN - 2587-0319 SP - 14 EP - 19 VL - 2 IS - 1 LA - tr AB - Amaç: Bu çalışmada; influenza benzeri hastalıktanımına uyan ve hastaneye yatırılan 75 olgu ile ilgili deneyimlerimizin paylaşılmasıamaçlandı.Hastalar ve Yöntem: PZR (polimeraz zincir reaksiyonu)yöntemiyle RNA (ribonükleik asit) tespit edilmiş pandemik 2009 influenzapozitif olgular ile negatif olguların yaş, cinsiyet ve altta yatan hastalıkilişkileri, laboratuvar ve radyolojik görüntüleme sonuçları, hastanede ve yoğunbakımda yatış süreleri ve taburculuk şekilleri karşılaştırıldı. Bulgular: Her iki grup arasında cinsiyet dağılımı,yaş ve akciğer grafisi bulguları açısından anlamlı bir fark görülmedi. Gruplararası laboratuvar parametrelerinden CRP(C-reaktif protein) ve plateletdüzeyleri karşılaştırıldığında arada anlamlı fark bulunurken beyaz küre,hemoglobin, nötrofil ve lenfosit sayıları açısından arada anlamlı farkbulunmadı. H1N1 pozitif grupta ortalama CRP miktarı H1N1 negatif gruba göreanlamlı olarak daha yüksek düzeyde bulundu. H1N1 pozitif grupta ortalamaplatelet miktarı anlamlı olarak H1N1 negatif gruba göre daha düşük bulundu. Sonuç: Pandemik H1N1 influenza olgularının kliniktakipleri oldukça önemlidir. Altta yatan kronik hastalık zemininde pandemikinfluenzanın (H1N1) bazı vakalarda fatalseyredebileceği düşünüldü. KW - H1N1 KW - influenza KW - oseltamivir KW - PZR KW - pnömoni N2 - Aim: In this study, we aimed to share our experience with75 patients admitted to the hospital who adhered to the definition of influenza-likeillness.Patients andMethods: Pandemic 2009 influenza positiveand negative cases with RNA (ribonucleic acid) detected by PCR (polymerasechain reaction) method were compared in terms of age, gender and underlyingdisease relationships, laboratory and radiological imaging results, hospitalstay and intensive care unit stay and discharge patterns. Results: There was no significant difference in sexdistribution, age and chest x-rayfindings between the two groups. When the CRP(C-reactive protein) and plateletlevels of the groups were compared between the groups, there was a meaningfuldifference between them, but there was no significant difference in terms ofwhite cell, hemoglobin, neutrophil and lymphocyte counts. The mean CRP level inthe H1N1 positive group was significantly higher than the H1N1 negative group.In the H1N1 positive group, the mean platelet amount was significantly lowerthan in the H1N1 negative group. Conclusion: Clinical follow-up of pandemic H1N1 influenza casesis very important. Pandemic influenza (H1N1) was thought to be fatal in somecases in the underlying chronic illness. CR - 1. Michael T. Brady, Carrie L, et al. Committee on Infectious Diseases, American Academy of Pediatrics. Recommendations for prevention and control of influenza in children, 2012-2013. Pediatrics 2012;130(4):780–92. CR - 2. Acar M, Sütçü M, Aktürk H, et al. Clinical differences of influenza subspecies among hospitalized children. Turk Pediatri Ars 2017;52(1):15-22. CR - 3. Jain R, Goldman RD. Novel influenza A (H1N1). Clinical presentation, diagnosis and management. Pediatr Emer Care 2009;25:791-6. CR - 4. Sullivan SJ, Jacobson RM, Dowdle WR, et al. 2009 H1N1 influenza. Mayo Clin Proc 2010;85:64-76. CR - 5. Dawood FS, Jain S, Finelli L, et al. Emergence of a novel swine-origin influenza A(H1N1)virus in humans. N Engl J Med 2009;360:2605-15. CR - 6. Erdin BN, Özbek ÖA, Duman M, ve ark. İnfluenza A (H1N1) pdm09 Tanısında Hızlı Antijen Testi ile RT-PCR Testinin Karşılaştırılması. Türk Mikrobiyol Cem Derg 2015;45(4):160-4. CR - 7. Sachedina N, Donaldson LJ. Paediatric mortality related to pandemic influenza A H1N1 infection in England: an observational population-based study. The lancet 2010;376:1846-52. CR - 8. American Academy of Pediatrics Committee on Infectious Diseases. Recommendations for Prevention and Control of Influenza in Children, 2016–2017. Pediatrics 2016;138(4):e20162527. CR - 9. S Kohno, MY Yen, HJ Cheong, N Hirotsu, et al. Phase III Randomized, Double-Blind Study Comparing Single-Dose Intravenous Peramivir with Oral Oseltamivir in Patients with Seasonal Influenza Virus Infection. Antimicrob Agents Chemother 2011;55(11):5267-76. CR - 10. Harper SA, Bradley JS, Englund JA, et al. Seasonal influenza in adults and children---diagnosis, treatment, chemoprophylaxis, and institutional outbreak management: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis 2009;48:1003-32. CR - 11. Seema J, Kamimoto L, Bramley A, et al. Hospitalized Patients with 2009 H1N1 Influenza in the United States, April-June 2009. N Engl J Med 2009;361:1935-44. CR - 12. Torres SF, Iolster T, Schnitzler EJ, et al. High mortality in patients with influenza A pH1N1 2009 admitted to a pediatric intensive care unit: a predictive model of mortality. Pediatr Crit Care Med 2012;13:78-83. CR - 13. LM Napolitano, PK Park, KC Sihler, et al. Intensive-Care Patients With Severe Novel Influenza A (H1N1) Virus Infection -Michigan, June 2009. MMWR Morb Mortal Wkly Rep 2009:58:749-52. CR - 14. Acar M, Sütçü M, Aktürk H, et al. Clinical differences of influenza subspecies among hospitalized children. Turk Pediatri Ars 2017;52:15-22. 15. Lee E, Seo JH, Kim HY, et al. Clinical characteristics and outcomes among pediatric patients hospitalized with pandemic influenza A/H1N1 2009 infection. Korean J Pediatr 2011;54(8):329-34. CR - 16. Hoenigl M, Prattes J, Drescher, et al. Comparison of clinical presentation and laboratory values at admission between PCR-confirmed influenza A H1N1 infection and influenza-like disease, South-East Austria. Infection 2014;42(2):317-24. 17. Wang SM, Liao YT, Hu YS, et al. Immunophenotype expressions and cytokine profiles of influenza A H1N1 virus infection in pediatric patients in 2009. Hindawi Publishing Corporation Disease Markers 2014;2014:6. CR - 18. Hackett S, Hill L, Patel J, et al. Clinical characteristics of paediatric H1N1 admissions in Birmingham, UK. Lancet 2009;374(9690):605. CR - 19. Libster R, Bugna J, Coviello S, et al. Pediatric hospitalizations associated with 2009 pandemic influenza A (H1N1) in Argentina. N Engl J Med 2010;362:45-55. CR - 20. Rasmussen SA, Jamieson DJ, MacFarlane K, et al. Pandemic Influenza and Pregnant Women: Summary of a Meeting of Experts. Am J Public Health 2009; 99(Suppl2):248-54. CR - 21. O’Riordan S, Barton M, Yau Y, et al. Risk factors and outcomes among children admitted to hospital with pandemic H1N1 influenza. CMAJ 2010;182:39-44. CR - 22. Wang SF, Tseng SP, Loh EW, et al. Generation and characterization of new monoclonal antibodies against swine origin 2009 influenza A (H1N1) virus and evaluation of their prophylactic and therapeutic efficacy in a mouse model. Dev Comp Immunol 2017;67:8-17. CR - 23. Huang SY, Huang WC, Chen YC, et al. Increased Mortality in Seasonal H3N2 Patients Compared with those with Pandemic 2009 H1N1 in Taiwan, 2009-2010. Am J Trop Med Hyg 2017;97(6):1945-51. CR - 24. Lang P-O, A Mendes, J Socquet, et al. Effectiveness of influenza vaccine in aging and older adults: comprehensive analysis of the evidence. Clinical Interventions in Aging 2012;7:55–64. CR - 25. Beck CR, McKenzie BC, Hashim AB, et al. Influenza vaccination for immunocompromised patients: systematic review and meta-analysis from a public health policy perspective. J Infect Dis 2012;206(8):1250–9. CR - 26. Zivich PN, Tatham L, Lung K, et al. Influenza vaccination status and outcomes among influenza-associated hospitalizations in Columbus, Ohio (2012-2015). Epidemiol Infect 2017;145(15):3284-93. UR - https://doi.org/10.30565/medalanya.368195 L1 - http://dergipark.org.tr/tr/download/article-file/444094 ER -