@article{article_391063, title={The Effects of Somatostatin Analogue SMS 201-995 (Ocreotide) and Omeprazole on Mechanical Intestinal Obstruction in Rats}, journal={Journal of Uludağ University Medical Faculty}, volume={29}, pages={11–14}, year={2003}, url={https://izlik.org/JA56ZH24MH}, author={Demircan, Celaleddin and Kapıcıoğlu, Sait and Kuşkonmaz, İbrahim and Taşkın, Abdullah and Günaydın, Murat and Kaya, Nadir}, keywords={İntestinal obstruksiyon, Somatostatin analogu, SMS 201-995, Octreotide, Omeprazol}, abstract={Objective: This study was designed to test the effects of a long-acting somatostatin analogue SMS 201-995 (Octreotide) and omeprazole, a proton pomp inhibitor, on experimental intestinal obstruction in rat model. Methods: Albino male rats (average weight, 150-200 gr) were used for experiment. Rats were fasted for 24 hours. After they were anesthetized by inhalation with ether, the laparotomy were made for construction of a 10 cm closed-loop of terminal ileum. The rats were randomized to receive SMS 201-995 (Octreotide) 50 μg/kg (n:10), saline 0.5 ml (n:10) and omeprazole 7 mg/kg (n:10) subcutanously every 8 hours. Omeprazole was given only one dose, the other 2 doses were given as saline. Twenty four hours after the first dose of treatment the rats were sacrificed and the small bowel removed. The weight of closed-loops and the volume of luminal contents were measured. pH and electrolytes (sodium, potassium, chloride) were analysed and the loops were examined histologically. Results: No significant changes in intestinal loop weight, luminal volume, sodium, potassium, chloride density, pH level and the gross and microscopik pathologic features of intestinal distension were observed with somatostatin analogue and omeprazole treatments when compared to control group. Conclusion: In this rat model of intestinal obstruction, the treatment unith somatostatin analogue and omeprazole for 24 hours did not appear beneficial.}, number={1}