@article{article_391077, title={Evaluation of Angiogenesis in Acute Leukemia Patients}, journal={Journal of Uludağ University Medical Faculty}, volume={29}, pages={1–6}, year={2003}, url={https://izlik.org/JA26UB53UY}, author={Özçelik, Tülay and Ali, Rıdvan and Özkalemkaş, Fahir and Özkocaman, Vildan and Ozan, Ülkü and Öztürk, Hülya and Tunalı, Ahmet}, keywords={Anjiyogenezis, Akut lösemi}, abstract={The importance of angiogenesis for solid tumors is well established. In contrast only few data are available for hematologic neoplasms. In our study we aimed to investigate the role of angiogenesis in bone marrow biopsies of untreated acute leukemia patients. Microvessel counts in the bone marrow biopsies of untreated patients were compared with normal controls and with ones counted at the time of complete remission. Thirteen patients were included in the study. Bone marrow samples were immunohistochemically stained with von Willebrand factor. Microvessels were scored in two areas of the highest microvessel density in sections of each bone marrow specimen. Angiogenesis was expressed as the number of vessels counted at x400 magnification. Bone marrow microvessel count was significantly increased in acute leukemia patients compared with controls (p<0,01). Additionally microvessel count at presentation was significantly higher than the one assassed at the time of complete remission (p<0,01). In conclusion by demonstrating increased angiogenesis in the bone marrow of acute leukemia patients we think that angiogenesis may play a role in the pathophysiology of acute leukemia.}, number={2}