@article{article_391236, title={The Ultrastructural Analysis Of The Effects Of Probucol On Endocrin Pancreas Tissue In Experimentaly Induced Diabetes Mellitus}, journal={Journal of Uludağ University Medical Faculty}, volume={31}, pages={5–8}, year={2005}, author={Karabay, Gülten and Erdoğan, Deniz and Take, Gülnur and Karasu, Çimen}, keywords={Deneysel diyabet, Probukol, Ultrastrüktür}, abstract={The aim of the present study is to investigate the protective effect of probucol, which is an antioxidant agent on beta cells in STZ induced diabetes mellitus model. In this study, 24, 7-8- week -old male rats, weighing 200-250 g were used, and the animals were divided into three groups. The control group received a single dose of sodium citrate (ip, n = 8), the 8 weeks chronic diabetes mellitus group received of a single dose 50 mg/kg STZ (ip, n = 8), the diabetes mellitus group received 300 mg/kg/day probucol for 3 weeks (n = 8). Electron microscopic examination revealed degenerative changes of mitochondria and Golgi complexes in diabetes mellitus group when compared with control group and beta cell granules were relatively decreased. When the samples from the diabetes mellitus group treated with probucol were evaluated, beta cell granule numbers were nearly normal, degeneration in organelle structure was reduced, but still present. As a conclusion probucol decreases the degenerative effects of diabetes mellitus on beta cells, but does not treat them all.}, number={1}, publisher={Bursa Uludağ Üniversitesi}