TY  - JOUR
TT  - The Ultrastructural Analysis Of The Effects Of Probucol On Endocrin Pancreas Tissue In Experimentaly Induced Diabetes Mellitus
AU  - Karabay, Gülten
AU  - Erdoğan, Deniz
AU  - Take, Gülnur
AU  - Karasu, Çimen
PY  - 2005
DA  - March
JF  - Journal of Uludağ University Medical Faculty
JO  - Uludağ Tıp Derg
PB  - Bursa Uludağ Üniversitesi
WT  - DergiPark
SN  - 1300-414X
SP  - 5
EP  - 8
VL  - 31
IS  - 1
KW  - Deneysel diyabet
KW  - Probukol
KW  - Ultrastrüktür
N2  - The aim of the present study is to investigate the protective effect of probucol, which is an antioxidant agent on beta cells in STZ induced  diabetes mellitus model. In this study, 24, 7-8- week -old male rats, weighing 200-250 g were used, and the animals were divided into  three groups. The control group received a single dose of sodium citrate (ip, n = 8), the 8 weeks chronic diabetes mellitus group received  of a single dose 50 mg/kg STZ (ip, n = 8), the diabetes mellitus group received 300 mg/kg/day probucol for 3 weeks (n = 8). Electron  microscopic examination revealed degenerative changes of mitochondria and Golgi complexes in diabetes mellitus group when compared  with control group and beta cell granules were relatively decreased. When the samples from the diabetes mellitus group treated with  probucol were evaluated, beta cell granule numbers were nearly normal, degeneration in organelle structure was reduced, but still present.  As a conclusion probucol decreases the degenerative effects of diabetes mellitus on beta cells, but does not treat them all.
UR  - https://dergipark.org.tr/tr/pub/uutfd/issue//391236
L1  - https://dergipark.org.tr/tr/download/article-file/420539
ER  -